Expression And Significance Of Snail And Claudin3in Adenomyosis

Objective:To explore the expression and significance of transcription factor Snail and tight junction protein Claudin3in ectopic and eutopic endometrium of adenomysis.Method:The expression of Snail and Claudin3was detected by the immunohistochemistry in the ectopic and eutopic endometrium of40cases with adenomyosis and in the normal endometrium of10cases.Results:1.The positive rate of Snail were90.0%,62.5%and50.0%in ectopic, eutopic and normal endometriums, respectively, there were significant differences among three groups(all P<0.05),and the positive rates in secretory and hyperplasia phases of eutopic and normal endoetrium, there were no significant differences between both two groups(all P>0.05).2.The positive rates of Claudin3were57.5%、85%and90.0%in ectopic, eutopic and normal endometriums, respectively, there were significant differences among three groups(all P<0.05);and the positive rate in secretory and hyperplasia phase of eutopic and normal endometrium, there were no significant differences between both two groups(all P>0.05).3.There is. a negative correlation between the expression of Snail and Claudin3in ectopic endometrium of adenomyosis(P<0.05).Conclusions:Upregulation expression of Snail and downregulation expression of Claudin3in adenomyosis, suggest that the abnormal endometrium cells conductive to migrate to myometrium, the negative correlation of them associated with the invasive biological behavior of endometrium; Snail and Claudin3were through the induction of epithelial-mesenchymal transition (EMT) to promote the pathogenesis of adenomyosis.