Serum25-hydroxyvitamin D Levels And Diabetic Retinopathy

ObjectiveTo explore the relationships between the serum levels of25-hydroxyvitamin D (25-OHD)and the development of diabetic retinopathy (DR) witn type2diabetes. In the paper, wesurveyed the variation of25-OHD, glycosylated hemoglobin (HbA1C), fasting insulin level(IRT), low-density liporotein cholesterol (LDL-C), total cholesterol (TCHO),et al. All thepatient’s fundus changes were examined and recorded. We explored the relationships betweenthe serum levels of25-hydroxyvitamin D (25-OHD) and the development of diabeticretinopathy. We provided guidance and advice for clinical prevention and treatment of DR byanalyzing the relationship between DR and various indicators, factors of DR.MethodAccording ADA diagnostic criteria for diabetes released in1997, we selected553houspital patients in our hospital with type2diabetes (329men,224women, age:52.56±12.2years,30-86years, duration of diabetes:9.61±7.03years,0.4-45years) and62healthy peoplewith heath checkup in our hospital in the same period. All patients were grouped according tofundus changes: The first group without diabetic retinopathy (NDR group,51.06±12.15years,n=179), the background retinopathy group (NPDR group,52.69±12.19years, n=374) and theproliferative retinopathy group (PDR group,54.81±12.06years, n=105).62persons withoutdiabetes were divided to the control group (NC group,52.58±13.20years, n=62). Checked and recorded all participants fundus changes and25-OHD, HbA1C, IRT, LDL-C, TCHOand others indicators and the general condition of patients. Analyzing data using statisticalsoftware SPSS17.0. Using mean±standard deviation represented test results. Correlationanalysis using pearson correlation analysis, partial correlation analysis and logistic regression.Result1General analysisSmoking(P＝0.475), drinking (P＝0.714) and sex (P＝0.1) and other general did notassociate with DR by using non-parametric test. The frequency of vitamin D deficiency wasno significant difference between NDM group and DM group, NPDR group and PDR group(P=0.072，P＝0.611). The frequency of vitamin D deficiency was statistically significantdifference between DR group and NDR group (P＜0.01).2Univariate nanalysisNDM group compared with DM group, age was no significant difference (P=0.10). Fromthen NDR NPDR PDR group to group, age, course of disease, blood pressur (BP), HbA1Cgradually increased (P＜0.05); LDL, HDL, Homa-IR and IS was no significant difference (P＞0.05).The25-OHD levels was statistically significant and in order to reduce between fourgroups.3Correlation analysisBy pearson correlation and partial correlation, analysis25-OHD did not associate withHoma-IR, FPG, IS adjusted for age and gender.4Logistic regression analysisIndicators with difference of significance included in logistic regression models, resultshowed course of disease, BP, and HbA1C was a risk factor for the happening anddevelopment of DR. High levels of25-OHD can prevent and delay the development of DR (P Conclusion1In four groups, difference of course of disease, SBP, and HbA1C were statisticallysignificance and were a risk factor for the happening and development of DR by using logisticregression. But25-OHD level was a protective factor of DR and prevented and delayed thedevelopment of DR (P <0.05).25-OHD deficiency prevalence of DR group was significantlyhigher than the NDR group showed25-OHD deficiency could predict the incidence of DR.2Probability of smoking, drinking, sex were no significant difference between fourgroups showed smoking, drinking, sex did not associated with DR.325-OHD did not associate with insulin resistance and insulin sensitivity.