The Clinical Analysis Of The Digestive Neuroendocrine Neoplasms

Purpose:Neuroendocrine neoplasm (NEN) was thought to be a rare tumor, but recent research has proved that the incidence of NEN has increased yearly. So it is important to analyze the clinicopathological features of digestive neuroendocrine neoplasms as well as the survival.Methods:All cases involving are patients diagnosed as NEN by pathology between January2000and January2012in the Cancer Hospital of Tianjin Medical University. Then the clinicopathological features and survivals are retrospectively reviewed.Results:There are163cases,95males and68females, among them, pancreas19, esophagus6, small intestine8, appendix and ileocecus12, colon14, rectum48, stomach56.Only one was suspected suffering from carcinoid syndrome. pT stage and histological classification were associated with metastasis of neuroendocrine neoplasms. The1-years and3-years survival rates of all cases are90.5%and74.4%respectively. Single factor analysis indicate that sex, age, primary tumor site, pT stage, histological classification, lymph node metastasis and distant metastasis are significantly associated with the prognosis(p<0.05). The multivariate Cox regression analysis further shows that the pT stage and distant metastasis are the major independent prognosis indicators.Conclusions:Man has a higher risk of digestive neuroendocrine neoplasms than women.Most of tumors locate in Colorectum and stomach. Carcinoid syndrome is not the common clinical symptoms. pT stage and histological classification are important metastasis factors of digestive neuroendocrine neoplasms. Sex, age, primary tumor site, pT stage, histological classification, lymph node metastasis and distant metastasis are related to the prognosis. Especially, pT stage and distant metastasis are the major independent factors of the poor prognosis.