| Objective: we explored the difference of histological, osteoclast differentiation andthe expression of molecules related to bone remodeling to better understand themechanism in alveolar decortications-facilitated accelerated orthodontics.Method: In this study,50rabbits were randomly divided into5groups of10rabbitseach. The left side of the mandible served as the experimental side, which was treatedby modified alveolar decortication–facilitated orthodontics and the right side served asthe control side. A4oz force was applied to the mandibular first molar. The animalswere sacrificed on days1,3,5,7and14. Three of the animals at each time point were used for histological observation. The other five animals were used for molecularstudies.Result: Cone beam CT demonstrated that the amount of tooth movement wassignificantly greater in the experimental group on days1,5, and7. On day14, thedistance was almost the same. Histological observation demonstrated a higher count ofosteoclasts and bone remodeling activity in the experimental group. In addition, themRNA expression of CTSK and TRAP was markedly upregulated on the5th day, theCTR mRNA was expressed evenly on days1through7, and the trend of JDP2andNFATC1expression was consistent, reaching its highest on the7th day.the Fra2,RANKL/OPG expression increased on the5th day and was significantly higher on days5,7, and14days, the OCN mRNA was significantly higher on days5,7,14days. TheRUNX-2was significantly higher on days3day.Conclusions: In summary, conclusions were as follows:1)modified alveolardecortication–facilitated orthodontics can accelerate the tooth movement, but does notincrease the total distance of tooth movement;2) osteoclast mechanism plays a moreimportant role in the modified alveolar decortication–facilitated orthodontics than theosteoblast mechanism on the early time of tooth movement; and3) Osteoclast mayformated doubled in the modified alveolar decortication–facilitated orthodonticsprocedure. |
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