Analysis Of Renal Biopsy In610Patients With Clinical And Pathological Type

Objective: Analysis of gender、age、histological type and clinical manifestationsin inour hospital610cases of renal biopsy patients, providing valuable information for thediagnosis and treatment of disease.Method:Collceted from January2004to January2014in the Second AffiliatedHospital of Dalian Medical University,610cases of hospitalized patients with renalbiopsy, clinical manifestations and laboratory test data，pathological classifications weremade according to the WHO criteria of1982for renal pathology and modified in1995renal pathology type the revised scheme and combined with clinical data, laboratory testresults, and renal pathology diagnosis, According to the patient’s age, sex,compositionof primary disease and type of renal pathology statistics, and compare before and afterfive years the pathological type of change.Results:1. A total of610cases of patients with primary glomerular disease (PGD)468cases accounted for (76.72%), secondary glomerular diseases (SGN)142casesaccounted for (23.28%), PGD in IgA nephropathy (IgAN) accounted for (32.69%),followed by membranous nephropathy (MN) accounted for (27.99%), mesangialproliferative glomerulonephritis nephritis (MsPGN)(26.06%); SGN the most threecommon diseases were: hepatitis B virus associated glomerulonephritisaccounted for(35.91%), lupus nephritis accounted for (26.76%), allergic purpura nephritis accountedfor (24.64%).2. Gender distribution: Men accounted for306cases (50.16%), women accounted for304cases (49.84%). In PGD males accounted for248cases (52.99%), womenaccounted for220cases (47.01%), in SGN, males accounted for58cases (40.85%),women accounted for84cases (59.15%), primary glomerular disease and secondaryglomerular disease have significantly different distribution of men and women (P<0.01).3. Age distribution: In the primary glomerular disease disease25to34years thehighest proportion, IgAN, MPGN and FSGS the three kinds highest proportion of25to34years of age; the proportion of MN in the55to64age group was significantly higherthan the other five kinds of pathology. Secondary glomerular diseases with the highestincidence of35to44years old. Lupus nephritis in up to25to34age group theproportion, then gradually decreased with increasing age, the proportion of allergicpurpura in High15to34age group,the highest proportion of hepatitis B virusassociated glomerulonephritis places35to44age group.4.Analysis of pathological changes before and after five years of primary glomerular nephritis, statistical differences (P<0.01), from2009to2014MN detectionrate increase significantly, compared with other pathological types exist statistical significance (P<0.05). And secondary glomerular disease on the whole there was no significant statistical significance (P>0.05).5. Pathology and clinical manifestations of relationships, the group of patientswith nephrotic syndrome (NS)(44.10%) is the most common, followed by nephritic syndrome (GH)(39.20%), chronic renal failure (14.60%), acute renal failure(ARF)(1.80%), occult glomerulonephritis (0.30%).Conclusion：1. Primary glomerular disease is the most common glomerular diseasein which the highest proportion of IgA nephropathy, membranous nephropathyincreased incidence; hepatitis B virus associated glomerulonephritis is secondaryglomerular diseases the most common cause.2. Young adults is a high risk of glomerulonephritis, the proportion of secondaryglomerular diseases exist significant differences between men and women, andfemaledominant. 3. Nephrotic syndrome is the most common clinical type.