Hydrotalcite And Pantoprazole Have A Comparative Research In The Treatment Of Reflux Esophagitis

Objective:To observing the Reflux Esophagitis (Reflux Esophagitis, RE) patients in thealuminum magnesium carbonate Pan Li methadone treatment before and after theclinical curative effect and gastroscope Esophagitis healing situation, the review ofthe adverse drug reaction and Epidermal Growth Factor Receptor (Epidermal GrowthFactor Receptor, EGFR) expression changes, discusses aluminum magnesiumcarbonate in Reflux Esophagitis in clinical curative effect and the expression andclinical significance of EGFR in RE.Methods:According to the latest published in2005, the American gastroenterologicalassociation guide to the diagnosis and treatment of reflux esophagitis [1], and in2000the Chinese medical association of digestive endoscopy to formulate the diagnosisand treatment of reflux esophagitis (trial)[2], by gastroscope examination, choose60cases of our hospital in November2012-October2013digestive internal medicineoutpatient clinic and hospital diagnosed as reflux esophagitis patients. Refluxesophagitis patients sex of the selected in accordance with the doctor order number,according to random number table randomly assigned into the observation group andcontrol group: observation group (33cases) to give1.0g aluminum magnesiumcarbonate dar two hours after the meal warm water bubble, more Pan Li ketone10mgTid oral half an hour before meals, treatment cycle for eight weeks; Control group (31cases) for panxi tora azole40mg Bid since morning on an empty stomach and takebefore going to bed more Pan Li ketone10mg Tid oral half an hour before meals,treatment cycle for8weeks. Included in the observation group and control grouppatients before treatment and8weeks after treatment, respectively, determination ofblood routine, liver and kidney function, blood, urine, dung line electronic gastroscopy and used immunohistochemical method for determining the expressionlevel of EGFR.Results:Before treatment between two groups of patients with heartburn, acid reflux, andchest pain symptoms integral comparison differences had no statistical significance (P>0.05); According to groups of8weeks after solution treatment, the two groups aftertreatment can significantly reduce the RE symptoms integral, comparing the twogroups have significant difference (P <0.05); After treatment symptoms integralcomparison between the two groups had no statistical significance (P>0.05); Beforetreatment between two groups of endoscopic esophagitis reflux sex performancecomparison difference has no statistical significance (P>0.05), two groups of patientsin8weeks to check the gastroscope, endoscopic cure rate and effective than there wasno statistically significant difference (P>0.05), between the two groups aftertreatment compared with no statistical significance (P>0.05); According to groups of8weeks after solution treatment, adverse reactions after treatment between the twogroups have significant difference compared (P <0.05); EGFR positive expressionrate before treatment between the two groups there was no statistical significance (P>0.05) difference comparison, according to the treatment groups8weeks aftertreatment, two groups of EGFR positive expression rate was significantly decreased,the differences have statistics (P <0.05).Conclution:1. The curative effect of hydrotalcite ease RE patients clinical symptoms anddiazepam tora azole, aluminum and magnesium carbonate greatly reduce the adversedrug reactions, and can quickly neutralize acidic and alkaline reflux, ph in thetreatment of mixed reflux has broad application prospects.2. Aluminum magnesium carbonate may through the expression of EGFRpromotes the reflux esophagitis, healing, EGFR may be in the process of repairingesophagitis plays an important role.