Clinical Observation And The Relevant Factor Analysis Of Acute Skin And Oral Mucous Membrane Reactions In Patients With Nasopharyngeal Carcinoma For Concurrent Radiochemotherapy

objectiveTo observe the acute skin and mucous membrane reactions of98cases treatedwith concurrent radiochemotherapy for nasopharyngeal carcinoma, and analyze theinfluencing factors.MethodsA total of98nasopharyngeal carcinoma cases treated with concurrentradiochemotherapy were enrolled.17clinical and laboratory indexes were selectedweekly, including radiation dose, degree of the acute oral mucous and skin reactionsand blood routine test.ResultsUnivariate analysis showed that, the risk factors related with the occurrence ofthe acute oral mucous reactions were smoking history（X2=11.428，P=0.022）、diabetes history（X2=28.138，P＜0.001）and not using antibiotic at early stage ofmucositis（X2=31.292，P＜0.001）;the risk factors related with the serious degree of the acute oral mucous reactions were BM（It=2.585，P=0.011）、hemoglobin valuesbefore and after1week of radiotherapy and single-dose of gross tumor volume (GTV)(t=-2.284、-2.423， P=0.25、0.17） and weight loss before and afterradiotherapy(t=-2.157，P=0.034）;the risk factors related with the occurrence of theacute skin reactions was diabetes history（X2=37.825，P＜0.001）；the risk factorsrelated with the serious degree of the acute skin reactions were BMI（t=2.022，P=0.046）、hemoglobin values before and after1week of radiotherapy(t=-2.091、-2.253，P=0.039、0.027）、hemoglobin values after2weeks of radiotherapy（t=-2.275，P=0.025）and weight loss before and after radiotherapy(t=-3.479，P=0.001）.The multiariable logistic regression analysis showed that, the risk factors relatedwith acute radioactive oral mucosa reactions were diabetes history（OR=11.587,95%CI:1.022～131.411,P=0.048）, not using antibiotic at early stage ofmucositis（OR=0.177,95%CI:0.061～0.510,P=0.001） and weight loss before andafter radiotherapy≥5kg（OR=7.202,95%CI:1.150～45.119,P=0.035）, while those withthe acute radiation skin reactions were diabetes history（OR=44.890,95%CI:5.959～338.221,P＜0.001）， hemoglobin values before1weeks of radiotherapy＞130g/L（OR=8.059,95%CI:1.188～54.680,P=0.033）and weight loss before and afterradiotherapy≥5kg（OR=4.990,95%CI:1.276～19.510,P=0.021）.ConclusionsIn the patients treated with concurrent radiochemotherapy for nasopharyngealcarcinoma, diabetes history、not using antibiotic at early stage of mucositis andweight loss before and after radiotherapy≥5kg might be the independent risk factorsof the acute radiation oral mucosa reactions, while diabetes history、hemoglobinvalues before1week of radiotherapy and weight loss before and afterradiotherapy≥5kg might be the independent factors of the acute skin reactions.