| Abstract:Objective:To establish a preparation method of diammonium glycyrrhizinate lipid complexes effervescent granules, and to evaluate its dynamic pharmacodynamics in vivo animal medicine. Method:The prescription and technology of diammonium glycyrrhizinate lipid complexes effervescent granules screening, to determine the best prescription proportion, and the effects of the granule preparation stability and related indexes; With diammonium glycyrrhizinate capsules as the reference preparation, respectively to the rabbit and Beagle dogs as experimental animal, investigation of diammonium glycyrrhizinate effervescent granules in the rabbit in vivo and diammonium glycyrrhizinate lipid complexes effervescent granules in Beagle dogs in vivo pharmacokinetics; the reference preparation and lipid complexes effervescent granule in mice blood and liver tissue in the drug distribution situation, and to study the protective effect of these two kinds of preparation on acuteliver injury in mice induced by chemical carbon tetrachloride. Results:The preparing diammonium glycyrrhizinate lipid complexes effervescent granules method was established successfully, it has good stability and reproducibility; The effervescent granules in the relative biological availability of rabbits and dogs were153.7%and149.8%; In mice, the drug concentration in the blood of effervescent granules is the reference2times medicine concentration, the drug concentration in liver tissue is the reference26times medicine concentration; The effervescent granules has obvious protective effects on acute liver injury in mice. Conclusion:The diammonium glycyrrhizinate lipid complex effervescent granules quality stability, bioavailability is improved, there are very significant liver targeting effect, protective effect on liver injury is better, is a kind of glycyrrhizic acid in oral dosage forms of new and high-efficient. |
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