A Controlled Study On The Sedative Effect Between Dexmedetomidine And Midazolam In The Postoperative Patients Of Hypertensive Intracerebral Hemorrhage

Objective:To compare dexmedetomidine and midazolam in the postoperative patients of hypertensive cerebral hemorrhage on breathing, blood pressure, heart rate, GCS score and the impact of rebleeding.METHODS:1.Select the54cases of neurological surgery hypertensive cerebral hemorrhage as the observed object.,40male while14female,the average age is (59.2+10.5).Randomly divided into fixed sedative dexmedetomidine treatment group (group D) and midazolam sedation group (group M).2hours later toextubation and start giving sedation. At the same depth of sedation, respectively, at4hours,8hours,12hours,16hours,20hours and24hours after sedation,recorded the patients of two groups tested respiratory rate, heart rate, blood pressure, GCS score and intracranial bleeding again.Comparison and analysis:2.1Oxygen saturation bwteen group D and group M at thhe following time points:before sedation,4hours,8hours,12hours,16hours,20hours and24hours after sedation, and the number of respiratory depression occurrence within24hours in the two group.2.2Hate rate bwteen group D and M group at above-mentioned time points:,and the heart rate fluctuations at each time point.2.3The number of cases of hypotension comparison group D and M occur within24hours.2.4The GCS score changes bwteen D group and M broup at the above-mentioned time points.5The incidence of intracranial further bleeding between group D and group M24hours after the sedation.(Evaluation criteria:volume of hematoma exceeds20ml, midline shift greater than1cm)Results:1.Changes in breathing:There is no respiratory depression cases happen in the group D, but six cases in group M. The incidence of respiratory depression in group D was significantly lower than M group, there is statistically significant between the two group (P<0.05).2.Changes in heart rate:In D group, at the ablve-mentioned time points, the heart rate compared with the previous downward trend, the decline was statistically significant;In group M,at four hours, at the ablve-mentioned time points,,the heart rate compared with the heart rate pre-sedation also decreased, statistically significant decline; Compared with M group, the heart rate after sedation in D group has greaterly decreased, the difference was statistically significant.(P<0.05).Bradycardia: There are three bradycardia cases in group D,in group M there are2bradycardia cases, the two groups showed no significant difference (P>0.051.000).3.Hypotension:There are2cases of hypotension in D group, one in M Group1the two groups showed no significant difference (P<0.05).4.GCS score:In Group D,compare the ablve-mentioned time points with the previous sedation, GCS score no significant change, there is no statistically significant; In group M,there is a downward trend, at these time points compared with the before sedation,the decline was statistically significant; comparison between the two groups, the difference was statistically significant.(P1>0.05P2<0.05P3<0.05)5.Intracranial rebleeding:There’s no intracranial rebleeding cases in the two group after24hours.(P>0.05)Conclusion:1.Dexmedetomidine have no respiratory depression, can be safely used in patients withnon-mechanical ventilation2.Dexmedetomidine can inhibit the body’s sympathetic nervous stimulant, slow the heart rate, reduce the body’s basal metabolic rate, can protect heart and brain and other organshave.3.The sedative effect of dexmedetomidine is satisfactory,it does not affect the judgment of the patient’s state of consciousnessof during sedation...