Predictive Value Of N-terminal Pro-brain Natriureticpeptide For Long-term Prognosis Of Patients With STEAMI After Emegency PCI

To evaluate predictive value of N-terminal pro-brain natriureticpeptide for long-term prognosis of patients with acute ST elevation myocardial infarction(STEMI) after emegency PCI.NT-proBNP was obtained from106patients with STEMI in our Hospital within24h after admission. The patients were divided into two groups:Group1with cardiac events, including death, cardiogenic shock and heart failure; Group2without cardiac events.Compared with patients in group2, NT-proBNP was significantly higher in group1(P<0.05); and left ventricular ejection fraction(LVEF) was significantly lower (P<0.05). The areas under ROC curve of NT-proBNP and LVEDD to predict cardiac event were0.801and0.476. Only LVEF and NT-proBNP had predictive values for the patients (all P<0.01). The optimal cutoff value of NT-proBNP to predict cardiac event was860ng/1, with a sensitivity of88.3%and a specificity of70.1%. Patients with NT-proBNP concentration above860ng/1had a higher rate of cardiac event, heart failure, cardiogenic shock and death (43.47%vs.13.33%, P<0.05). Variables associated with cardiac event in univariate analysis included NT-proBNP, LVEF and diabetes. After adjustment for the above variables using multiregression logistic model, NT-proBNP remained to be the dependent factors for prediction of cardiac events.The urgent percutaneous coronary intervention can decrease NT-proBNP levels and reduce LVRM and improve LVEF.NT-proBNP can predict the long term outcomes of STEMI patients.