The Effect Of Meglumine Adenosine Cyclophosphate On Early Acute Cerebral Infarction

ObjectiveTo explore the efficacy of acute cerebral infarction treated by meglumine adenosine cyclophosphate.MethodsOne hundred patients with acute cerebral infarction were randomly divided into two groups: Control group (n=50) received conventional therapy, and the observation group (n=50) accepted cAMP meglumine based on the conventional therapy. CSF and serum samples were obtained from the all patients at the time48h,7d,14d; VEGF and cAMP were determined with enzyme linked immunosorbent assay-sandwich technique, and to evaluate clinical neurological deficit scores of the both groups by national institute of health stroke scale.Results1. The changes of VEGF in serum:the levels of VEGF at the time48h,7d,14d from patients with the observation group in the acute stage were significantly higher than those of the control group (P<0.05), and more obvious at the time7d (P=0.023). The changes of cAMP in serum:the levels of cAMP at the time48h,7d,14d from patients with the observation group in the acute stage were significantly higher than those of the control group (P<0.05), and more obvious at the time14d (P=0.038).2. The changes of VEGF in CSF:the levels of VEGF at the time48h,7d,14d from patients with the observation group in the acute stage were significantly higher than those of the control group (P<0.05), and more obvious at the time7d (P=0.011). The changes of cAMP in CSF:the levels of cAMP at the time48h,7d,14d from patients with the observation group in the acute stage were significantly higher than those of the control group (P<0.05), and more obvious at the time14d (P=0.005).3.48h and14th day in the treatment, neurologic impairment difference scores of the observation group and control group were significant difference (P<0.05), and more obvious in the observation group (P<0.01).ConclusionsMeglumine adenosine cyclophosphate enhances VEGF and cAMP expression from CSF and serum in the early acute cerebral infarction,which was likely to participate in the protective role of cAMP meglumine in ischemia reperfusion.