The Correlation Of The Helper T Cell Differentiation With Platelets And Red Blood Cells

Objective Explore the mean of the platelets and erythrocytes in Thl and Th2cells during differentiation of Th cell. Methods According to4different combinations of experimental conditions,complete blood cell group、the group without PL、the group without RBC、the group without neither RBC nor PL, Each group to set the NS at control group, With low density of Antigen LS180(5×109、L) group and High density Antigen Hs180(3×1010/L), using statistical methods to analysis if there is significant difference in cytokines between the experimental and control groups. Results (1) each group of IFN-γ/IL-10change:Hs180experimental group (P<0.05) has statistics significance. Goes to RBC to go to the PL group with to go to the RBC group contrast:H180experimental group elevates (P<0.05), the control group and the Hs180experimental group drops (P<0.05).(2) each group of interferon acceptor change result:Goes to the PL group<whole blood cell group:Ls180experimental group and control group (P<0.05). With goes to RBC to compare, goes to RBC to go to the PL group control group to drop (P<0.05), Hs180experimental group elevates (P<0.05).(3) each group of IL-10change results:Goes to the PL group and the whole blood cell group contrast:Ls180and Hs180experimental group has the remarkable change (P<0.05). The blood corpuscle group with goes to the RBC group to compare, Ls180experimental group (P<0.05) elevates. Goes to the PL group with to go to RBC to go to the PL group contrast, Ls180experimental group elevates (P<0.05), H the S180experimental group drops (P<0.05).Conclusion Platelets are the key of starting Th cell differentiation to Thl-and Th2-type. When antigens invade, Activated platelets is an engine for Th differentiation into Th2. Erythrocyte immune status may be the choice between cell-mediated immunity and humoral immunity of the body selected underlying cause.