| Objective: Acute brain stroke is due to acute cerebral circulatory disturbance limits or overallbrain function deficiency syndrome, also known as acute cerebrovascular disease According tomodern epidemiology study, stroke is a serious harm to people’s lives and health of commondiseases, is one of the three major causes of death in at present, China’s population, with a highincidence of high mortality rate high morbidity poor prognostic features, cause serious economicburden to family and society and national and spiritual loss, has become an important publichealth problem of our country national economy and people’s livelihood With ischemic stroke orcerebral infarction, serious impact on human health Especially in the acute phase of cerebralapoplexy, due to the severe brain edema Brain injury, the patient mortality is the highest, andacute phase becomes the key to the treatment.Atorvastatin (lipitor) is3-hydroxy-3-methyl glutaric acid and auxiliary A (HMG COAreductase inhibitor, belongs to the third generation of statins, with water-soluble and fat-soluble,affected by the diet is very small, it is mainly used for the prevention and treatment of disease ofheart head blood-vessel, its main function is the cholesterol triglyceride and low densitylipoprotein cholesterol (hdl-c), etc., in recent years, atorvastatin in treatment of stroke play ananti-inflammatory antioxidant antithrombotic stable plaques Pleiotropic effects such as reverseplaques have a lot of brain protection This article discusses different dose atorvastatin treatmentof acute cerebral infarction clinical curative effect, which will provide a scientific basis forclinical application and safety.Methods: For randomized into standard cases, between January2012and February2012, ourhospital90cases with acute cerebral infarction patients, the new one month before the admissionis not taking any other lipid-lowering drugs, exclusion of hemorrhagic cerebrovascular diseaseRheumatic heart disease serious arrhythmia Serious heart failure in malignant tumors systemicinfection autoimmune diseases Liver and kidney function is not complete Has a history of severetrauma or major surgery recently Have rheumatoid infectious embolism disease around thethyroid diseases Connective tissue disease Patients with anemia or malnutrition. Patients wererandomly divided into routine dose of20mg of atorvastatin treatment group30cases (group A)and40mg of atorvastatin treatment group30cases (group B),60mg of atorvastatin treatmentgroup30cases (group C), three groups are on the basis of conventional treatment to differentdose atorvastatin, observed before and after14days treatment of lipid (include: total cholesterol CHOL, triglyceride TG1low density lipoprotein LDL high-density lipoprotein (HDL)high-sensitivity c-reactive protein (hs-CRP) liver function (including: alanine aminotransferaseALT door winter transaminase AST) creatine kinase (CK) NIHSS score,14d after atorvastatinwere changed to20mg/d. Using SPSS16.0statistical software to deal with all the clinical dataand experimental data, measurement data are expressed as a mean standard deviation (s) x,Group in comparison with paired t test, the comparison between the LSD test data for statisticalanalysis and significance test, with p <0.05showed significant statistical significance difference.Results:1. Atorvastatin cholesterol-lowering effect strongest group C, group B, group A is weakest.2. Atorvastatin anti-inflammatory strongest antioxidant effect group C, group B, group A is theweakest.3Three groups in the aspect of improve nerve function score results no significant difference.4. Three groups of side effects: liver creatine kinase has no obvious difference before and afterthe treatment.Conclusions: Atorvastatin besides have obvious lipid-lowering effect, Also has goodanti-inflammatory antioxidant effect,60mg of atorvastatin group in lipid-loweringanti-inflammatory strongest antioxidant, short-term use safety is better. |
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