Association Of Serum PGRN (Progranulin) With Obesity And Type2Diabetes Mellitus

Objective：To evaluate the association of serum PGRN with type2diabetes mellitusand obesity，and to analyze the correlation between PGRN and the parameters of body fat,glucose and lipid metabolism, insulin sensitivity, to explore the role of PGRN in obesityand type2diabetes pathogenesis.Methods：On the basis of body mass index（BMI），44subjects with normal glucosetolerance were divided into overweight and obesity group (A group BMI≥25kg/m2) andnormal weight group (B group，18.5kg/m2≤BMI<25kg/m2),44newly diagnosed patientswith type2diabetes mellitus were divided into overweight and obesity group (C group，BMI≥25kg/m2) and normal weight group (D group，18.5kg/m2≤BMI<25kg/m2). Bloodpressure， Height, weight, waist circumference(WC),Hip circumference(HC), totalcholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C),lowdensity lipoprotein cholesterol (LDL-C), glycosylated hemoglobin (HbA1c), fasting plasmaglucose，et al were determined in all subjects. Body mass index (BMI), waist-to-hip ratio(WHR) and homeostasis model assessment for insulin resistance index (HOMA-IR) werecalculated.Results：Compared with normal glucose tolerance group, the levels of PGRN inpatients with type2diabetes mellitus were higher (P<0.01). Compared with A group andB group, the levels of PGRN in C group were higher (P<0.01). Simple correlationanalysis showed that in T2DM group PGRN was positively correlated with BMI、WHR、FBG、HbA1C、 CRP、TG、WC（r=0.340，P<0.01； r=0.504，P<0.01； r=0.539，P<0.01； r=0.652，P<0.01； r=0.495，P<0.01；r=0.252，P<0.05；r=0.342，P<0.01）,but negatively with HDL-C (r=-0.236，P<0.05). Furthermore, multiple regression analysisshowed that CRP was the independent factor of serum PGRN level (β=2.61，P<0.01).Conclusion：(1) The level of PGRN in serum of type2diabetes patients was higherthan that of the normal control group, diabetes with overweight and obesity group wassignificantly higher than those two sub groups in non diabetes mellitus group.Thesesuggest that elevated PGRN levels may promote the occurrence of obesity and type2 diabetes mellitus.(2) PGRN was positively correlated with BMI, WHR, FBG, HbA1C, CRP, TG andWC,negatively correlated with HDL, so good controlling of fasting blood glucose andglycosylated hemoglobin, weight loss can decrease the level of PGRN, possibly delayingthe progress of diabetic course.(3) CRP is an independent factor of PGRN, this suggesittng that PGRN may beinvolved in inflammation，so PGRN may be involved in various inflammatory reactionsincluding type2diabetes.