Effect Of Dexmedetomidine, Propofol And Midazolam On Cardiac Function In Elderly Patients In ICU

Objective To investigate the effects of dexmedetomidine, propofol and midazolamon cardiac function in elder patients in intensive care unit（ICU）．Methods Thirty postoperative elder patients with gastrointestinal tumors andrespiratory insufficiency, ASA grade II~III, were randomly divided into dexmedetomidine,propofol and midazolam group （n=10per group）. The patients were sedated afteradmitted to the ICU2hours later. Sedating drug was adjusted every30minutes accordingto the modified OAA/S score to maintain a calm grade3~4. The cardiac function wasrecorded before sedation（T0）, at60min（T1）,120min（T2） and180min（T3）aftersedation with echocardiography.Results Compared with propofol group, the ejection fraction（EF）, and fractionalshortening（FS）were increased in dexmedetomidine group at T1（P＜0.05）; In propofolgroup, mitral flow E peak speed（E） decreased at T1and T3than that at T0（P＜0.05）;The E speed of propofol group was lower than that of dexmedetomidine and midazolamgroup at T1（P＜0.05）; No significant differences were found in other parameters.Conclusion The above change of EF and E peak speed were significant but slightly.There is no significant impact on cardiac function when sedated with dexmedetomidine,propofol and midazolam.