CT Perfusion Imaging Of Rabbit Brain With Low Radiation Dose And Low Contrast Agent Load In The Feasibility Study

Objective: To evaluate the feasibility of low dose CT perfusion imaging of brain.Materials and Methods: Twenty New Zealand white rabbits underwent cerebralCT perfusion imaging twice with tube voltage70kV and tube voltage80kV, and the checkinterval is24h. The effective dosage (E)、cerebral perfusion parameters (CBF、CBV、MTT)and image quality indicator (SNR) of middle cerebral artery of each protocol wereacquired and compared statistically.Results: The effective dosage of70kV group and80kV group were1.91and2.93mSv, the effective dosage of70kV group reduced for34.8%as compared with that of80kV. There were no significant differences between the cerebral perfusion parametersacquired at different corresponding ROI. SNR of70kV group and80kV group were(23.15±5.98) and (21.23±9.18), there were not significant.Conclusion: The effective dosage of70kV cerebral CT perfusion imaging could bedramatically reduced and the results of perfusion parameters and image quality were aboutthe same. Objective: To evaluate the feasibility of low concentration and low dose iodinecontrast agent in CT perfusion imaging of rabbit brain.Materials and Methods: Fifteen New Zealand white rabbits underwent cerebral CTperfusion imaging three times with protocol A(Ultravist:350mgI/ml, total dose:9ml);protocol B(Ultravist:350mgI/ml, total dose:6ml); protocol C(Ultravist:270mgI/ml, totaldose:6ml), and the flaw rate is1.5ml/s, the check interval is24h. The cerebral perfusionparameters (CBF、CBV、MTT) and image quality indicator (mean CT values and SNR) ofmiddle cerebral artery at peak time of each protocol were acquired and comparedstatistically.Results: There were no significant differences between the cerebral perfusionparameters acquired at different corresponding ROI. Mean CT values of middle cerebralartery at peak time of three groups were （439.83±37.86）、（421.33±30.58）、（408.67±23.89）HU and SNR were (17.89±5.89)、（16.59±4.71）、（17.08±3.77）， therewere not significant.Conclusion: It is indicated that the application of low concentration and low doseiodine contrast agent can reduce iodine load, while the results of perfusion parameters andimage quality were about the same.