Clinical Analysis Of Prognostic Factors Of The Cerebral Venous Sinus Thrombosis

Objective：To define the factors which lead to poor prognosis by analysed the factorsthat may affect the prognosis of CVST (Cerebral venous sinus thrombosis, CVST).Provide a reference for grasping the patient’s condition comprehensively andaccurately, and taking positive and effective measures of treatment.Methods：Review the86CVST patients who was diagnosed in our hospital from May2008to February2014. The patients outcomes were divided into two categories,including good prognosis(mRs score≤2points) and poor prognosis(mRs score>2points). Combined with clinical data and follow-up results, Screening the risk factorsthat may affect the prognosis. Univariate analysis using χ2test or Fisher exact test.Logistic regression analysis was used to determine the multivariate independentfactors associated with prognosis.Results：In the86patients with CVST,54were male，32were female, the average ageis41.3years.①Hematoma,coma, subarachnoid hemorrhage, dyskinesia, superior sagittalsinus thrombosis, increased MPV and hypertension are the risk factors that lead topoor prognosis in the86patients. Coma and movement disorders are the independentpredictor of poor prognosis.②Patients with spontaneous and secondary CVST were31cases and55casesrespectively. There were higher disability or death rates in patients with secondaryCVST than in patients with spontaneous Intracranial hematoma, coma, dyskinesia，MPV increased and diagnosis time（<3days）affect the prognosis of the31patientswith spontaneous CVST. The prognosis of the55patients with secondary CVST isassociated with infarction, coma and dyskinesia. Cerebral infarction, coma, dyskinesiaare independent predictor that lead to poor prognosis.③There were33CVST patients resulting from mechanical injury,53resultingfrom non-mechanical injury. Univariate analysis showed that infarction and dyskinesia affect the prognosis of the33patients resulting from mechanical injury.Intracranial hematoma, subarachnoid hemorrhage, coma, hypertension, dyskinesia,higher MPV，older than43years and diagnosis time（<3days）were the risk factorsfor poor prognosis in53patients resulting from non-mechanical injury.Conclusions：The overall prognosis of CVST patients is good, there are still somecertain disability/mortality. Coma and movement disorders are the independentpredictor of poor prognosis. Majority patients were diagnosed in non-acute phase,explaining that we still need pay more attention and strength understanding on thisdisease, so as to diagnosis and treat CVST in an early time.