Prognostic Analysis Of Glioma Patients Receiving Postoperative Intensity-modulated Radiation Therapy

【Objective】To analyze the survival of glioma patients receiving postoperative intensity-modulated radiation therapy and investigate the related prognostic factors.【Methods】A retrospective data of glioma patients receiving first post-operative intensity-modulated radiation therapy from October2009to June2013in radiation oncology department at the First Affiliated Hospital of Fujian Medical University.The patients’ data including age、gender、tumor pathology、pathological grade、whether concurrent chemo-radiotherapy、tumor location、tumor maximum diameter、whether pre-operative epilepsy、radiation dose、the expression of GFAP、Olig2、 O6-methyl-guanine-DNA-methyltransferase (MGMT)、the expression level of Ki67and survival time.The one year、two-year and three-year overall survival time was calculated. Kaplan-Meier analysis was used to calculate survival and Log-rank analysis was used to compare survival differences between groups. The prognosis was analyzed by Cox multivariate model.【Results】87patients were adopted in my study and84patients had been followed up.The follow-up rate was96.5%(84/87).The follow-up time was1-48months with the median follow-up time was14months.All of patients’median survival time was36months.The recurrence cases were23and the death cases were24.The1year、2-and3-year OS rate were84.8%、67.5%and48.8%,respectively. Univariate analysis show that the survival of age＜42years group was better than age≥42yeas group’s one(P=0.026);the without epilepsy group’s survival was better epilepsy group’s one(P=0.018); Ki67<10%group’s survival was better than Ki67≥10%group’s one(P=0.015).The pathological grade higher,the survival poorer, P<0.001.Cox multivariate analysis show that the pathological grade was an independent prognostic factor for overall survival in glioma, P<0.001. 【Conclusions】The pathological grade was an independent prognostic factor for overall survival in glioma,the pathological grade higher,the prognosis poorer.