The Clinical Significance And Changes Of Lipoprotein-Associated Phospholipase A2Level In Patients With Acute Coronary Syndrome

Objective To discuss the relationship between the level of lipoprotein-associated phospho-lipaseA2(Lp-PLA2) and the degree of the coronary arterydisease and plaque stability in patients with acute coronary syndrome (ACS) andinvestigate the clinical significance.Methods79cases(46male cases and33female cases) were collected tohospital in line with the enrolled patients in in February2011to September2011.All Subjects were divided into ACS group and control group according to the resu-lts of coronary angiography(CAG), and then ACS group was divided again into different groups according to the clinical symptoms, number of diseased coronarybran ches and Gensini scores. Fasting serum specimens from patients weremeasured by ELISA the level of Lp-PLA2, and Simultaneous detection of blood,blood glucose, lipids and hs-CRP and other laboratory parameters.And recordspatient age, gender, blood pressure, body mass index (BMI) and other relevantclinical information.Results①The level of Lp-PLA2was higher significantly in ACS groupthan that in the control group (P<0.01).②The level of Lp-PLA2was highersignificantly in the group of acute myocardial infarction (AMI) than that in thegroup of unstable angina pectoris (UAP,P<0.01)；The level of Lp-PLA2was highersignificantly in three-vessel disease subgroup than that in single-vessel diseasesubgroup (P<0.01),and the level of Lp-PLA2was no significant difference among three-vessel disease sub-group and single-vessel disease sub-group, comparedwith the two-vessel disease sub-group(P>0.05).With the increase of Gensini score,the level of Lp-PLA2increased too.③Spearman rank analysis method showed thatthe level of Lp-PLA2was positively correlated with the WBC(r=0.346， P<0.05); wasnegatively correlated with the HDL-C（r=-0.320， P＜0.05)；had no correlation withTC,TG,LDL-C,hs-CRP,Fbg,Systolic blood pressure,Diastolic blood pressure and BMI（r=0.133、0.153、0.058、0.005、0.039、0.259、0.020、0.070、0.063,P=0.210、0.177、0.363、0.487、0.406、0.056、0.452、0.336、0.353）.Conclusion1. The level of Lp-PLA2was higher significantly in ACS groupthan that in the control group(p<0.01).2. The level of Lp-PLA2may reflect indire-ctly the degree of the coronary artery disease and plaque stability in patients withacute coronary syndrome (ACS).3. The level of Lp-PLA2was positively correlat-ed with the WBC； was negatively correlated with the HDL-C； had no correlationwith TC,TG,LDL-C,hs-CRP,Fbg, blood pressure and BMI.