Synthesis Of Amphiphilic Block Copolymers With Different Topology Structure And Their Self-assemblies

Amphiphilic block copolymers (BCPs) with "hydrophilic-hydrophobic" structure have been paid much attention since their unique properties and wide application prospects. The self-assembling of amphiphilic block copolymers is able to yield various morphologies and interesting structure no matter in bulk or in dilute solution. With the rapid development of synthesis method, increasing block copolymers with complex structure and composition were reported. Especially, functional block copolymers, such as block polypeptides enrich the block copolymer system as well.In this paper, we firstly synthesize amphiphilic block copolymers with different topology:PEO-b-PS and G2-b-PS270 and confirm their accuracy by 1H NMR, GPC, etc. By "co-solvent" method, we assembled the copolymers in diverse solvent (DMF/THF/1,4-Dioxane) and yield aggregates with multiple morphologies. By contrast, we discuss the effect of different topologies, copolymer composition and solvents to morphologies. Then, the thiol-ended copolymers were loaded to golden nanoparticles (AuNRs) by "Nitrogen-Sonication" ligand-exchange method. In this way, the copolymer/AuNRs amphihpilic molecular "brush" was prepared. We assemble the "brush" and obtained ordered aggregates containing multiple AuNRs. By contrast, we discuss the effect of different topologies, copolymer composition and solvents to morphologies.In the second part of this paper, we successfully prepared amphiphilic block polypeptides:PBLG-b-PCysPEGMA by NCA-ROP combined with "click" reaction and a consecutive adding method. By self-assembling BCPs in different solution, aggregates with different morphologies were obtained. By contrast, we discuss the effect of different topologies, copolymer composition and solvents to morphologies.