Synthesis And Properties Study Of Sulfur Heterocyclic Compounds

Organic heterocyclic compounds have a wide application in medicine, synthesis, materials and other aspects. There are three major types such as organonitrogen compounds, oxygen-containing organic compounds and organosulfur compounds. Numerically, organosulfur compounds mianly exists in the petroleum and animal or plant body, behind organonitrogen compounds or oxygen-containing organic compounds.In this paper, we designed and synthesized six novel sulfur heterocyclic bis-b-diketones, five novel bis-1H-pyrazoles derivatives, six novel bis-b-diketone boron difluoride compounds, six novel bis-b-diketone boroacetate compounds, eight novel bis-chalcone derivatives and twelve triazolothiadiazole derivatives. The main work is divided into six chapters:1. Six sulfur heterocyclic bis-b-diketones were synthesized from 1,1’-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)diethanone by Claisen condensation with six aromatic esters using potassium tert-butoxide as catalyst and characterized by FT-IR, 1H NMR, elemental analysis and mass spectrometry. Their UV-vis absorption spectra were also investigated in DMF solution.2. Five bis-1H-pyrazoles derivatives derived from bis-b-diketones were prepared by cyclization with hydrazine hydrate and characterized by FT-IR, 1H NMR, elemental analysis, the UV-vis absorption spectra and mass spectrometry.3. Six bis-b-diketone boroacetates derived from bis-b-diketones were prepared by chelation reaction with boroacetate and characterized by FT-IR, 1H NMR, elemental analysis and mass spectrometry. Their optical properties were investigated by UV-vis absorption, fluorescence spectroscopy.4. Six bis-b-diketone boron difluoride compounds derived from bis-b-diketones were prepared by chelation reaction with boron trifluoride and characterized by FT-IR, 1H NMR, elemental analysis and mass spectrometry. Their optical properties were also studied by UV-vis absorption, fluorescence spectroscopy.5. Eight bis-chalcone derivatives derived from 1,1’-(3,4-dimethylthieno-[2,3-b]thiophene-2,5-diyl)diethanone were synthesized by Aldol condensation with aromatic aldehydes and characterized by FT-IR, 1H NMR, elemental analysis and mass spectrometry. All bis-chalcone derivatives exhibited a certain degree of anti-bacterial and anti-fungal activities.6. Twelve triazolothiadiazole derivatives derived from carbon disulfide and substituted benzoyl hydrazines were synthesized and characterized by FT-IR, 1H NMR, elemental analysis and mass spectrometry. All the triazolothiadiazole derivatives exhibited a certain degree of anti-bacterial and anti-fungal activities.