Application Of Magnetic Nanocatalyst CuFe O ₄ In Nitrogen Heterocyclic Synthesis And Benzyl Alcohol Oxidation

N Heterocycles widely occur in medicine, natural products, and biologically active molecules, and they play an important role in the design and discovery of new drugs. However the uneasily available precursors and undesired by products limit their wide applications. Therefore, the development of novel, efficient and practical methods for heterocycle synthesis is an important goal in modern organic synthesis.Direct conversion of primary alcohols to the corresponding aldehydes is still a pivotal reaction in organic synthesis. However, most of these traditional oxidation processes might suffer from some drawbacks such as the rarity and price transition metal catalyst, ligand together with strong base conditions, metal contamination in the end products and undesirable stoichiometric oxidants, which should still impede their applications on a large scale. In view of the principles of green chemistry, the novel, efficient and recyclable catalysts is still challenging in the current chemistry.The copper(II) ferrite nanoparticles were prepared according to the literature procedure, and were characterized by X ray diffraction, SEM and TEM. The copper nanoparticles were used to compound N Heterocycles and aldehydes.(1) Copper nanoparticles catalyzed synthesis of nitrogen, oxygen heterocyclicsA green and efficient strategy for the synthesis of benzoxazoles, benzothiazoles and benzimidazoles has been developed by using inexpensive, readily available, dioxygen stable and recyclable CuFe2O4 as the nanocatalyst, and o substituted aminobenzene and various aldehydes as the starting materials. The CuFe2O4 nanoparticles are dioxygen insensitive and easily recoverable with an external magnet from the reaction medium. The catalyst can be reused ten times without significant loss of catalytic activity.(2) Copper nanoparticles catalyzed synthesis of aldehydesA novel, effective and sustainable strategy for the synthesis of aldehydes has been developed CuFe2O4 nanoparticles as the catalyst. The corresponding substituted aldehydes were obtained in moderate to good yields by aerobic oxidation of aromatic alcohols in water under dioxygen atmosphere. Importantly, a ligand or a base was not necessary.By the methodologies above, thirty three kinds of nitrogen, oxygen heterocyclics and fifteen kinds of aldehydes were prepared and characterized.