Numerical Analysis Of Biosensors Based On Piezoelectric Effect

Quartz crystal microbalance (QCM) has been widely utilized in physical, chemical, environmental and biological analyses based on its high sensitivity, low cost and real-time detection. Multichannel quartz crystal microbalance (MQCM) is proposed on a single quartz wafer which can detect and separate multi-component samples at the same time. MQCM used for bond-rupture scanning has been designed, simulated and verified in this paper to expand the application fields of biochemical analysis and environmental monitoring. Based on QCM and MQCM chips, bond-rupture scanning is a biosensor which can distinguish the specific and nonspecific interactions in analyte. The x-displacement is choosen as the parameter to evaluate the properties of newly designed QCM and MQCM chips. The bond rupture force is also connected with x-displacement. Based on the finite element method, QCM models with different parameters of electrode and quartz plate were simulated and analyted in this paper. The MQCM models were designed and simulated in the same way. The main purpose of this paper is studing the relationship between x-displacement and design parameters of QCM chips. Based on the simulation results, we can obtain the optimized parameters to design new QCM chips with higher x-displacement and stronger bond rupture force.Based on our research, the x-displacefment and the bond rupture force were proportional to the amplitude of AC voltage. For single QCM, the distance between the edge of electrode and the edge of quartz plate should be larger than3.28mm in order to reduce the possibility of coupling interference. For MQCM, the x-displacement with value of6.57×10-11m can be obtained from the model of QCM array, nearly twice than single QCMs with the value of3.5×10-11m. The bond rupture force gained from3×3QCM array also increased nearly twice than single QCMs. Thus, MQCMs designed by optimized parameters could generate larger x-displacement and stronger bond-rupture force. This will be the new reference to achieve practical sensing devices with high sensitivity and wide applications.