In Patients With MCP-1, NT-proBNP And LVEF Correlation Between Acute Coronary Syndrome

Objective To investigate the relationship between serum levels of monocyte chemoattractant protein(MCP-1), N-terminal pro-brain natriuretic peptide(NT-proBNP) and left ventricular ejection fraction(LVEF)in the patients with acute coronary syndrome(ACS). And further explore the value of evaluating the prognosis of these indicators tested in the patients with acute coronary syndrome (ACS).Methods The total of89patients with ACS were enrolled in this study. All cases were inpatients during November of2012to March of2013from Department of Emergency of Affiliated Hospital of Qingdao University Medical College,including62cases of acute coronary infarction(AMI) and27cases of unstable angina pectoris(UA).Serum concentration of MCP-1was detected by enzyme-linked immunosorbent assay(ELISA)The levels of plasma NT-proBNP was determined by anautomated electrochemiluminesce immunoassay.Other indicators such as Hs-cTNT, CK-MB, Cr, BUN, et al were measured in all subjects by the laboratory of Affiliated Hospital of Qingdao University Medical College.All cases were checked by Doppler echocardiaogyaphy after hospitalization in ten days. they were divided into group A≤40%, group B41%-55%, group C>55%, according to left ventricular ejection fraction (LVEF). Correlation analysis was made between MCP-1and NT-proBNP and LVEF. In addition,89patients with ACS were divided into acute coronary infarction (AMI) group and unstable angina pectoris (UA) group,different levels of indicators above-mentioned were compared.All data were analyzed with SPSS version19.0statistical package. Normally distributed data are expressed as the mean, standard deviation, applied t-test for the comparison of two groups, and one-way analysis of variance (ANOVA) was used for multi-group; Non-normally distributed data were expressed as medians (minimum and maximum values), Kruskal-Wallis rank sum test was used for comparison; The log-transformed NT-proBNP levels were used, as the values were not normally distributed. The relationship between continuous variables was analyzed by Pearson correlation. A p value<0.05was considered statistically significant. Results1.Among A(LVEF≤40%),B (LVEF41%-55%),C(LVEF>55%) groups, the higher MCP-1levels are, the higher NT-proBNP levels are. The linear correlation analyses demonstrated that serum MCP-1levels were positively correlated with log NT-proBNP levels (r=0.551, P<0.05); inversely, the lower MCP-1and logNT-proBNP levels are, the higher LVEF are, the linear correlation analyses demonstrated that both MCP-1and log NT-proBNP levels were negatively correlated with LVEF(r=-0.609, P<0.05or r=-0.636,P<0.05).2. According to the types of ACS, it is no significant difference in MCP-1and NT-proBNP between AMI.and UA. However, the LVEF has statistical significance among the two groups.Conclusion Serum levels of MCP-1and NT-proBNP are associated with LVEF of ACS. Those markers may be helpful to the risk-stratification and prognosis for ACS, and are expected to provide a new strategy for the prevention and treatment of patients with ACS. However, it is no obvious correlation with the type of ACS.