| Objective:Through the clinical studies to evaluate kidney nerves decoction safety and efficacy in treating liver-kidney intractable insomnia.Methods:By the China Academy of Traditional Wangjing Hospital Sleep Disorders clinic meets the inclusion criteria topic liver-kidney patients with intractable insomnia, observing them as objects, and the62patients enrolled in the treatment of the order by using a simple random draw grouping method, which is divided into kidney nerves soup group (31cases) and estazolam tablets group (31cases); during the study, kidney nerves soup group and estazolam group has one case the program fails to take drugs, excluding cases not included in the statistics. Ultimately included in the statistics of60cases of liver-kidney patients with intractable insomnia. Two groups were given kidney nerves soup and estazolam tablets oral treatment, kidney anshen decoction according to traditional Chinese medicine liquid form of oral method, each one in the morning and evening, take6days,1day rest; Estazolam tablets1mg, taking half an hour before sleep,1week as one period of treatment, treatment of two period of treatment. Cases according to project into the standard filter into the group, on the day of the not taking medication, medication treatment2weeks, and after the treatment of the first week, the three time points using the Pittsburgh sleep quality index (PSQI) between the two way and curative effect before and after contrast observation in the group, compare the curative effect of the change difference between two groups, as well as the two groups before and after treatment in patients with Pittsburgh sleep quality index score changes, by SPSS17.0statistical data from two groups of patients before and after treatment, and record the work time of patients and adverse reactions.Results:1.The first two groups of patients with intractable insomnia gender, age, disease duration, disease classification, sleep time comparison, both have P>0.05, the difference was not statistically significant, indicating that the former two groups of patients in terms of gender, age, disease duration, disease classification, comparable to the sleep time.2. The total effect of the experimental group before and after the treatment group and the control group, the experimental group the cure rate was90.00%, control group was73.33%, indicating that the two groups before and after treatment of liver and kidney in patients with intractable insomnia sleep were improved; overall efficacy between the two groups liver-kidney patients with intractable insomnia compared using the X2test, P=0.001<0.01, the difference was statistically significant, indicating that the total effect of the nerves around the kidney soup group patients than estazolam group.3. Between the experimental group and the control group, the total effective rate before and after treatment, using the X2test, P=0.095>0.05, the difference was not statistically significant, indicating that the treatment of kidney and liver-kidney nerves soup intractable insomnia and estazolam the total efficiency of the same chip.4. Sleep time before and after testing the treatment group and the control group were compared within the group, stratified data by X2test, both groups P<0.05, before and after sleep time described two groups of patients were improved; between the two groups sleep time after treatment, stratified data by X2test, P=0.308>0.05, the difference was not statistically significant, indicating that the improvement in kidney and liver soup nerves in patients with kidney intractable insomnia sleep duration and estazolam the same piece.5. The experimental group and control group before and after treatment Pittsburgh Sleep Quality Index total score, hierarchical data by X2test, both groups P<0.05, the difference was statistically significant, indicating that the two groups of patients before and after treatment PSQI total scores were lower; PSQI total score between the two groups after treatment, the data layer by X2test, P=0.686>0.05, the difference was not statistically significant, the treatment of kidney and liver-kidney nerves soup intractable insomnia description, Its PSQI total score and estazolam tablets PSQI total score after treatment is similar.6. According to the Pittsburgh Sleep Quality Index will be between the two groups of patients before treatment, after treatment, after stopping score, divided into three grading the quality of sleep, after three times before and after the treatment condition scores between the two groups before the treatment hierarchical distribution of the disease after treatment stratified data by X2test, P>0.05, the difference was not statistically significant, indicating that the disease between the two groups before and after treatment were similar classification.1week after discontinuation, patients were stratified by disease classification data distribution X2test, P<0.05, the difference was statistically significant, indicating that the withdrawal one week after the distribution of the different groups of patients the disease classification and treatment of disease classification group distribution than the control group, that is, one week after the withdrawal, the test group of patients to improve the quality of sleep is still more obvious, rebound, and no drug dependence does not appear. However, in the control group, patients with sleep quality is still poor, worse insomnia significantly increased, there has been a slight drug dependence.Conclusion:Two groups of patients before treatment, gender, age, disease duration, disease classification, sleep time compared were comparable; total efficiency between the two groups before and after treatment, sleep time, the Pittsburgh Sleep Quality Index total scores are the same, that the two drugs in the treatment of liver-kidney intractable insomnia total efficiency, sleep duration, Pittsburgh sleep Quality Index total score on, has the same effect; comparing the total effect of the two groups before and after treatment, with a statistically significant difference, indicating that the two groups of liver kidney in patients with intractable insomnia sleep have improved, and the total effect of kidney patients before and after therapy was superior sedative soup estazolam group; before treatment, the disease after treatment grading distribution is not statistically significant, indicating that the disease between the two groups before and after treatment were similar classification; withdrawal one week after illness treatment group than the control group classification, the treatment group improved quality of sleep is still more obvious, rebound, and no drug dependence does not appear. However, in the control group, patients with sleep quality is still poor, worse insomnia significantly increased, there has been a slight drug dependence.Kidney anshen decoction is Xu Lingyun teacher through years of clinical experience in the research, and in the overall concept of traditional Chinese medicine and syndrome differentiation and treatment system under the guiding principle, through many years of clinical curative effect observation and form the experience of the party. It is used in the treatment of liver and kidney Yin deficiency type of stubborn sex insomnia, have nourishing liver and kidney, calming nerves sedative effect. And is safe and effective in the treatment of liver and kidney Yin deficiency type of stubborn insomnia, not only can prolong the sleep time, improve the quality of sleep, and no drug dependence and side effects, is worth the clinical research and application promotion. |
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