EA Under The Combined Influence Of The Large Intestine On The Giant Virtual Hole Functional Constipation In Patients With R-fMRI Brain Functional Connectivity Effect Immediately

Objective:to study the differences in rest-state functional magnetic resonance imaging (resting-state fMRI) images between patients with functional constipation being treated with electro-acupuncture on the acupoint Shangjuxu, the lower Hexue of the Large Intestine Meridian, and patients with functional constipation treated with sham acupuncture (needing of non-acupoint, non-meridian section near the midpoint of the Stomach and Gall Bladder Meridian).This preliminary study hopes to find a connection between electro-acupuncture of the Shangjuxu acupoint and activated brain cortexes to provide imaging evidence for the central mechanism of acupuncture and its treatment of functional constipation.Methods:20patients with functional constipation who met the inclusion criteria underwent a homogenous cross-comparison. Electo-acupuncture to the Shangjuxu acupoint (observation group) and ipsilateral non-acupoint, non-meridian point (control) were given on the third day at the same time. By screening the activating effect of the most active right insular cortex seed resting state of the two groups before and after acupuncture-using functional connections as observed indicators and MATLAB, DPARSF and REST software for image processing and statistical analysis to find the respective presence of functional connections with the right insular cortex area of the brain image and then analyze the resting-state of the two groups-the connection differences between before and after electrical stimulation and the differences between the two groups before and after electrical stimulation can be visualized.Result:1Patients with functional constipation in the resting state have the following activated brain regions:(REST One sample T-test, P<0.05); negative activated brain regions: the posterior lobe of the right cerebellar hemisphere, the left cerebellar hemisphere posterior lobe of the right parietal lobe precuneusthe right parietal lobule brain regions (REST One sample T-test, P<0.05), the amount of the left frontal lobe back.2In contrast to the resting-state, electro-acupuncture to the Shangjuxu acupoint negatively activates the right frontal inferior frontal gyrus and the right precuneus (REST Paired T-test, P<0.05). In contrast to the resting-state, electro-acupuncture to the non-acupoint, non-meridian point negatively activates the right precentral gyrus, the left precentral gyrus (REST Paired T-test, P<0.05).3In comparison to electro-acupuncture to the non-acupoint group, electro-acupuncture to the Shangjuxu acupoint activates several areas with increased functional connectivity (REST Two-sample T-test, P<0.05); negatively activates the several areas (REST Two-sample T-test, P<0.05).4Comparison of the two resting states:several areas are strongly linked (REST Two-sample T-test, P<0.05); decreased functional connectivity in the left superior frontal gyrus (REST Two-sample T-test, P<0.05)Conclusion:1Under normal conditions, the brain is a task-quiet, calm case with certain functional activities-a resting brain default network. In contrast, there are some differences in the default network resting-state in patients with functional constipation. The main differences between the two are the activated areas of the brain associated with emotional processing and visceral hypersensitivity. This finding needs to be further validated.2Electro-acupuncture on the Shangjuxu acupoint correlates with higher cognitive brain areas, which relates to decreased functional connectivity. The clinical effect on the treatment of functional constipation and anxiety relief may be related to this change. There is a strong link between electro-acupuncture to the non-acupoint group and changes in the functional somatic sensory area, which may clinically relate to the stimulation of the body associated with acupuncture.3Electro-acupuncture on the Shangjuxu acupoint can activate the cognition, emotion, and memory regions of the brain, amongst others, and reduce the visceral hypersensitivity; therefore, the Shangjuxu point can effectively improve the symptoms of patients with functional constipation and depression, may be related to the above changes.4In the same group of subjects’ before and after, the two resting-state brain function network images are slightly different. A small portion of the emotional and cognitive functional areas of brain were found to have a strong functional connection, which may be related to the subjects’ emotional response to the testing dynamic.