Association Study On The Traditional Chinese Medicine Types Of Syndrome Of Chronic Hepatitis B Fibrosis And Objective Detective Signs

Objective.In order to find the relationship of fibrosis serologic target and Traditional ChineseMedicine Type of syndrome, the characteristic of syndrome, and the most commonsyndrome type of chronic hepatitis B fibrosis, we do this study. After that, we can open outthe essential of syndrome and the rule of syndrome and external target with the method ofintegration of syndrome differentiation and disease differentiation, and make a base fordrawing up a standard and canonical diagnosis and treatment system with TCM, which willmake TCM develop along the modern medicine, and give full play to the characteristic andsuperiority of TCM, to prevent or interdict liver fibrosis and improve survivalqualityintegrating of macrocosmic and microcosmic, distinguish hiberarchy and steps,primary and secondary, or cooperative, supporting the vital energy and removing the evil.Methods:Adopt the method of observing cases and laboratory detect. The cases were 230altogether who were from clinic and in-patient department in Dec. 2005 to Dec. 2006. Andthey were diagnosed as chronic hepatitis B and liver fibrosis. Write down the detailinformation including the medical record, symptoms, syndrome type, and the laboratoryresults asALT, AST, HBV-DNA, and PCⅢ,ⅣC, LN, HA, etc. Andthen, collect allthe information and make a database, and make the result by SPSS13.0 software, managedescriptive statistics, use rank sum test to manage ordinal data, use analysis of variance forquantitative data, and rank sum test if it is not homogeneity of variance, 2-tail, a=0.05.Results:1.Of the whole 230 cases of chronic hepatitis B, most of the cases is the stagnation ofliver-energy and spleen deficiency type; the cases of the retention of evil wetness-heat type and accumulated blood stasis Type is less.The liver and the kidney yin-deficiency type,the spleen and the kidney yang-deficiency type have the least cases.2.The stagnation of liver-energy and spleen deficiency type is the most in themasculine cases ofPCⅢ,ⅣC, LN, HA. The sequence of the masculine cases of PCⅢ,LN, HA is stagnation of liver-energy and spleen deficiency type, the liver and the kidneyyin-deficiency type, the spleen and the kidney yang-deficiency type, the retention of evilwetness-heat type, and accumulated blood stasis typ. The sequence of HA,ⅣC isstagnation of liver-energy and spleen deficiency type, the retention of evil wetness-heattype, the liver and the kidney yin-deficiency type, the spleen and the kidneyyang-deficiency type and accumulated blood stasis type. The sequence of LN is stagnationof liver-energy and spleen deficiency type, the retention of evil wetness-heat type, thespleen and the kidney yang-deficiency type, the liver and the kidney yin-deficiency typeand accumulated blood stasis type.3.The ALT and AST among dampness-heat accumulation group and liver-depressionand spleen asthenia group were remarkable higher than the other three groups (P＜0.05).The ALT/AST in blood-stasis in collaterals was 0.91.It had statistically significance in eachgroup(P＜0.05).4.In the different level of liver function, the level ofⅣC is different (p=0.019). Thesequence is the worst liver function, the worse liver function, the normal liver function,the bad liver function.5.The HBVDNA in dampness-heat accumulation group and blood-stasis in collateralgroup were remarkable lower than that of other three groups(P＜0.05). On the contrary,the precore mutation in dampness-heat accumulation group and blood-stasis in collateralgroup was remarkable higher than that of other three groups(P＜0.05).6.HBeAg in the liver and the kidney yin-deficiency type were remarkable higher(66.7％) than liver-energy and spleen deficiency type and accumulated blood stasis type.HBeAb in the retention of evil wetness-heat type were remarkable higher (88.4％) thanliver-energy and spleen deficiency type and the liver and the kidney yin-deficiency type. Conclusions:Stagnation of liver-energy and spleen deficiency type is the most common in chronichepatitis B with liver fibrosis. Stagnation of liver-energy and spleen deficiency, retention ofevil wetness-heat, the liver and the kidney yin-deficiency, the spleen and the kidneyyang-deficiency and accumulated blood stasis are the different phases of chronic hepatitisB and liver fibrosis as disease develops. As the state aggravating, the degree of liverfibrosis was increasing. In deficiency cases, the level of the replicate of HBV-DNA shouldbe lower than the other type.