| Hepatic fibrosis is a prosthetic response to chronic liver injury, still a stage ofdevelopment of kinds of chronic hepatopathy to cirrhosis of liver. The mechanism ofhepatic fibrosis is the imbalance of synthesis and degradation of extracellular matrix (ECM)by regulation of many kinds of cells and cytokines. Recently, a lot of data indicate hepaticstellate cells (HSC) is the key cell of formation of ECM and HSC is also the core link ofoccurrenc of hepatic fibrosis. Various kinds of facts lead to damage of liver, then causeCellular necrosis of liver and inflammation. The first intracellular mediator ofTGF-βsignalling that had been identified was Drosophila MAD (Mothers againstdecapentaplegic), which is involved in the signaling cascade of dpp (decapentaplegic, theDrosophila homologue to TGF-β) signaling [Sekelsky, 1995]. The first vertebratehomologue reported was the tumour suppressor DPC4 (Deleted in Pancreatic Carcinoma, locus 4). Intracellular proteins that mediate signalling from receptors for extracellular TGFβ-related factors. Smad2 is essential for embryonic mesoderm formation and establishmentof anterior-posterior patterning. Smad4 is important in gastrulation. Smad1 and Smad5 areactivated (serine/threonine phosphorylated) by BMP receptors, Smad2 and Smad3 byactivin and TGF-βreceptors. Smads activated by occupied receptors then form complexeswith Smad4/DPC4 and move into the nucleus where they regulate gene expression. Theincidence of the chronic hepatitis and hepatic fibrosis is 59.36%, among which there isabout 25%-40% would develop the liver cirrhosis. The major factor in China was theepidemic HBV. Liver cirrhosis is always thought to be the irreversible pathological state, while hepatic fibrosis reversible one. How to stop the progression of the hepatic fibrosisseems critical to the therapy. Up to date, the western medicine has not efficient drugs todeal with chronic liver disease while Chinese medicine and herbs has its advantage intreating it.Methods the research guided by the theory of the traditional Chinese medicine investigate the cause, the mechanism, the pathology and the therapy. We hold the opinionthat the hepatic fibrosis is caused by the dampness heat and epidemic toxin, the irregulationof the diet, the imbalance of the emotion. The basic mechanism is the impairment of theliver, kidney, spleen, Qi is silted with Xue. The pathological factor include the dampness, heat, toxin, siltation etc. The principle of the therapy could be divided into two parts, theearly stage of the disease is based on soothing the liver and strengthening the spleen, clearing away the heat-evil and eliminating wetness, regulating the flow of qi and activatingblood circulation, while the advanced stage nourishing the liver and invigorating kidney, supplementing qi and strengthening the spleen, activating blood circulation and eliminatingwetness. The Landou Hepatoprotecting Granule from the celebrity professor zouliangcaihas the conclusive effect on the disease after many years clinical research. With the modernadvanced technology, this research aimed to elevate effects of Landou HepatoprotectingGranule composed with completely Chinese herbs on the experimental hepatic fibrosis inrats, compared with results from Colchicine. By detecting serum biochemical changes, routine pathologic changes and immune pathological changes and others, the exact effectsof Landou Hepatoprotecting Granule on protecting liver from hepatic fibrosis and itstherapeutic mechanism may be elucidated. Result Landou Hepatoprotecting Granule has agood effect on preventing rats from the damage caused by carbon tetrachloride. It candecrease the production of Smad4, reduce the deposition of the extracellular matrix, andprevent liver from hepatic fibrosis. Studying in the Chinese herbs aimming to prevent fromhepatic fibrosis is established while inchoate clinical diagnosis on hepatic fibrosis wouldalso be benefited. |
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