Pharmacetic Studies On Jinning Oral Liquid For Children

Jinning Oral liquid for children, which is mada from Flos lonicerae, Fructus RuctusForsythiae, Herba Schizonepetae, Herba Menthae and other four kinds of herbs, is acompound preparation for treating chlidren’s catching cold by fever. The main researchcontents on Jinning Oral liquid for children include technology of the preparation, qualitystandards, the stability of the pharmaceuticals and the effect of medicine.1. Formula Components AnalysisWe pay a point to decrease the components of the original prescription and enhancecompliance on the foundation of guaranteeing the original valids. By comprehensiveconsideration of the preparational indicators and pharmacodynamics, we determined thebest prescription is concluded by the eight kinds of Chinese herbs above.2. Technology of preparationDuring the research of the technology of preparation, we pay a point to choosing asuitable dasage on the foundation of guaranteeing the original valids and choosing areasonable technology according to its physics and chemistry character.First, because of it implies the volatile oil, we have a research on the volatile oilenveloping process: we take use of the orthogonal experimental design to obtain the bestprocessing to get the oil is: adding water in ten times, extracting eight hours.Second, according to the content of chlorogenic acid and total flavone, wu take use of theorthogonal experimental design to obtain the best processing is that: adding 12 timesamount of water, extracting 2 times and every time with 1.5 hours. Put the solution toghther, concentrate it to relative density of 1.10, accommodateion the concentration ofethanol to 60%, standing till decompress.Third, we compared the purificational effect of ultrafiltration, twice-alcohol precipitationand activated carbon absorption and we choose the method which can purifcation and holdas much as active ingredients. The result is ultrafiltration is the best way.Forth, based on single factor experiment, we find that the best content of simple syrup is30% and the kind of the essence is taste of hami melon.3. Study of quality standard During the quality research preceedings, we identified Flos lonicerae, Fructus RuctusForsythiae, Herba Schizonepetae, Herba Menthae and other two kinds of herbs by TLCmethod, which is special and accurate. The content of chlorogenic acid was determined byHPLC after the methodlogy was completed. The HPLC showed that the average recovery isup to standard and its precision, stability and reappearance was good. The experimentshowed that the content of chlorogenic acid should be more than 15mg in each bottle(10ml).4. Study of primary stabilityFor the sake of inspecting primary stability of Jinning Oral liquid for children, theroom-temperature and accelerating test were carried into execution, from which the resultsshowed every index marker was normal. It indicated the quality of Jinning Oral liquid forchildren was steady and controllable.In this paper, complied with the standard of new medicine researching of number6,firstly the author collects literature, then studies on preparation technics, standard ofquality, stabilization and the dissolve in vitro of plaster of xuetie dingchuan,and gives asummary.