An Experimental Study Of Carboxymethyl Chitosan/Fluorine Controlled-release Films

OBJECTIVE:To prepare porous carboxymethyl chitosan(CMC)/fluorine controlled-release films and study on their performance testing and release in vitro. Though evaluation the characteristics, mechanism and influence factors of the new material, provide theoretical information for development and improvement of the new fluorine controlled-release material.METHODS:To prepare porous carboxymethyl chitosan/fluoride controlled-release films by freeze-drying process, with polyvinylpyrrolidone(PVP) as porogen, different concentrations of sodium fluoride as an effective ingredient. The porosity and fluorine release rate were chosen as index to screen the optimal formulation of the preparation. The morphology of membrane was observed by scan electron microscope; With anhydrous ethanol liquid displacement method to detect the porosity; With fluorine ion standard curve study its drug release properties in vitro.RESULTS:1、The porous carboxymethyl chitosan/fluoride controlled-release films had optimal microstructure on surface, ideal aperture in200～450um range, while every hole was isolated, and hole wall was thick.2、The optimal porosity and fluorine release rate were determined when the ratio of CMC to PVP to sodium fluoride was1:1:1with porosity was23.36±2.33%and fluorine release rate was0.22mg/d.CONCLUSION:1、The porous carboxymethyl chitosan/fluoride controlled-release films had been produced. Which can be applied to surface of removable partial denture, on the one hand, local fluorine-release can strengthen the abutment teeth and play a preventive dental decay effect; on the other hand, it can increase the adaptation、comfortable and duration of prosthesis use.2、The porous carboxymethyl chitosan/fluoride controlled-release films had optimal porosity, and fluorine release rate was the safe and stable, and delayed drug release in vitro.3、The optimal porosity and fluorine release rate were determined when the ratio of CMC to PVP to sodium fluoride was1:1:1with porosity was23.36±2.33%and fluorine release rate was0.22mg/d and it were valuable to be studied further for prevention of overdenture secondary root surface caries and local fluorine-release of removable partial denture.