Study Of Prevalence And Related Factors Of Acute Stroke Patients With Depression After Stroke

BackgroundPost-stroke depression can make the patients’attention, learning,and the executive ability significant damage, which is not conducive to the recovery of limb function,seriously affect the treatment effect, and increased hospitalization and mortality. So, management of depression has focused inreasingly on preventive intervention as successful preventive strategies can reduce emotional suffering and dep ression-related morbidity and mortality. Prevention is better than cure, especially for depression, preventive interventions may reduce the overall incidence of depression by20--50%each year. Therefore, this requires the clinician to fully understand the incidence of post-stroke depression, in order to achieve the PSD patients should be early diagnosis, early treatment.ObjectiveTo investigate the incidence and related factors of acute stroke patients with depression after stroke.Methodsselect120cases of Acute cerebral infarction hospitalized in Dong E Hospital from November2012to November2013,including70male cases and50female cases. The diagnosis of Acute stroke was made according to the criteria established in the National Fourth Session of cerebrovascular disease academic conference in1995. The clinical characteristics were performed an average of2weeks after the onset of stroke using a standardized questionnaire. Post stroke depression (PSD) was considered to be present when either the Hamilton Depression Scale (HAMD) score or the ICD-10F06.32criteria were met.We calculated the incidence of PSD, and compared between the two groups in general between patients (including gender, age, residence, education level, recently personality, negative events,and the relationship between family members, family income, smoking history,drinking history), Vascular risk factors (including hypertension, diabetes, etc.), Stroke incidence, onset location, the degree of neural function defect, blood homocysteine, high-sensitivity C reactive protein, total cholesterol, triglyceride, low density lipoprotein,to understand the relevant factors influencing the occurrence of PSD.Results1. Mild and moderate PSD are more common. A total of120stroke survivors were studied,46cases were conform to the standard. The incidence of PSD is38.3%,including mild patients12(26.09%),moderate patients24(52.17%) and severe patients10(21.74%)2. There are many PSD related factors. The study found that PSD patients’ character before the onset, recent negative life events, family care, income and place of residence are associated with the occurrence of PSD (P<0.05);and sex, age, culture degree had no significant relationship with the occurrence of PSD (P>0.05).3. Vascular risk factors of hypertension, diabetes are related with the incidence of PSD, and more risk factors, more prone to PSD (P<0.05). smoking, drinking had no significant correlation with PSD (P>0.05).4. more stroke and stroke lesion number, more prone to PSD (P<0.05);From the stroke position, no significant statistical differences between the psd group and the non psd group, but the incidence of PSD are lower in patients with the stroke position on the right than the patients with the stroke position on the left side and bilateral.5. Patients with high NIHSS score of the first day are prone to suffer from PSD (P<0.05). 6. The relationship between PSD and blood index:PSD is associated with blood lipid of homocysteine and high sensitive C reactive protein (P<0.05). And homocysteine and high sensitive C reactive protein is higher, the more serious the degree of depression (P<0.05).7. Post-stroke depression is associated with cognitive impairment and neurological deficits.ConclusionsPost stroke depression is frequent after stroke with many more related factors and high incidence。Mild and moderate PSD are more common. PSD patients’character before the onset, recent negative life events, family care, income and place of residence are associated with the occurrence of PSD. Multifocal PSD patients clinical incidence is higher than that of patients with single lesion. Vascular risk factors of hypertension, diabetes are related with the incidence of PSD.Post-stroke depression is associated with cognitive impairment and neurological deficits.