Relationship Of PhospholipaseA2with Ischemic Cerebral

Purpose: Measured by enzyme-linked immunosorbent assay levels in patients with ischemic stroke serum Lp-PLA2, and to explore the relationship between serum levels of Lp-PLA2and clinical various types of ischemic stroke and other risk factors for ischemic stroke between clearly its role in the pathogenesis of ischemic stroke.Objection: A randomized controlled study,the observation group,including100cases ischemic stroke patients of Affiliated Hospital of Qingdao University Medical College of Emergency Neurology from August,2012to August,2013.The control group,age and sex matched with the observation group,including50cases healthy subjects.All patients among them, the observation group were the first onset and were not taking anticoagulants and lipid-lowering drugs.Two groups of patients were admitted to hospital within24hours of fasting venous blood taken blood glucose, blood lipids [triglycerides (TRIG), cholesterol (CHOL), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)], Lp-PLA2, plasma high-sensitivity C-reactive protein (hs-CRP) levels, recording the history of smoking patients, blood pressure, neurological deficit (NIHSS score), ischemic stroke type (large artery atherosclerosis, small artery occlusion, cardioembolism) and other indicators, all data were statistically analyzed using SPSS17.0software.Results:1.In the observation group,the serum Lp-PLA2level was higher than that of the control group, independent samples t test showed that there was significant difference (P<0.01). Logistic regression analysis showed that Lp-PLA2is a risk factor for ischemic stroke.2.Multiple linear regression analysis showed: the observation group Lp-PLA2levels in patients with NIHSS scores were positively correlated with multiple linear relationship (P<0.05), and patients with hs-CRP, blood pressure, blood lipids, blood glucose levels were not correlated (P>0.05).3.Aarge artery atherosclerotic stroke group (LAA) and small artery occlusion stroke group (SAA) were compared between the control group and the serum Lp-PLA2level was statistically significant (P<0.05). Cardiogenic cerebral embolism group (CE) compared with the control group, serum Lp-PLA2levels were not statistically significant (P>0.05).Conclusion:1.High level of Lp-PLA2is a risk factor for ischemic stroke, the level of serum Lp-PLA2detection can evaluate the risk of ischemic stroke prevalence.2.The serum level of Lp-PLA2can reflect the ischemic cerebral apoplexy nerve function defect degree, but no significant correlation between the other risk factors and ischemic stroke.3.The correlation between Lp-PLA2in populations of different types of ischemic stroke is varied.