Prevalence Of Cognitive Impairment In Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease And The Risk Factors

Objective To investigate the prevalence of cognitive impairment in patients with acute exacerbation of chronic obstructive pulmonary disease and the risk factors.Methods Patients with COPD exacerbation and healthy people were recruited in the study, using the Montreal Cognitive Assessment(MoCA) to estimate cognitive function, analyzing the prevalence of cognitive impairment in patients with COPD exacerbation; The patients with COPD exacerbation were classified into different groups according to lung function and BODE index to observe whether the prevalence of comparison groups was different; Pearson correlation analysis was used to analyse the correlation between the score of MoCA and value of PaO2、value of PaCO2; Pearson chi-square test and multivariate logistic modeling were used to estimate the prevalence of cognitive impairment and the risk factors.Results1.Prevalence of cognitive impairment in Patients with COPD exacerbation was63.8%, it was significantly worse than healthy people(P<0.01);2.The difference between the prevalence of FEVl%pre≥50%and FEVl%pre<50%was not obvious(P>0.05), prevalence of the state of illness was evidently different(P<0.01);3.Pearson correlation analysis revealed:the score of MoCA had positive correlation with value of PaO2(r=0.396,P<0.01)and had negative correlation with value of PaCO2(r=-0.572, P<0.01);4. Logistic regression analysis showed that cognitive impairment in patients with COPD exacerbation was associated with education level、 course of disease and BODE index, the patients who with longer course of disease、higher BODE index and lower education level had higher risk to be accompanied with cognitive impairment(P<0.05), However no significant difference was observed between age、sex、smoking status and cognitive impairment(P>0.05).Conclusions This study confirmed the high prevalence of cognitive impairment in patients with COPD exacerbation, and the prevalence in FEV1%pre≥50%and FEV1%pre<50%was not different, prevalence of the state of illness was evidently different. The score of MoCA had positive correlation with value of PaO2and had negative correlation with value of PaCO2. Course of disease and BODE index were the risk factors for cognitive impairment in patients with COPD exacerbation, but education level was the protective factor.