Analysis Of Pathogen-distribution And Microbial Sensitivity Of Urine Culture In Hospitalized Patients In2012

Objective To investigate the distribution of pathogens and drug resistance of urine culture in hospitalized patients.Methods Results of urine culture and microbial sensitivity of hospitalized patients in the Affiliated Hospital of Medical College, Qingdao University in2012were analyzed retrospectively.Results A total of583strains of pathogen (47.79%) were separated, of which, Gram-negative bacteria, Gram-positive bacteria and fungi accounted for61.06%,26.59%and12.35%,respectively,and Escherichia coli (34.13%), Enterococcus faecium(11.66%), Klebsiella pneumonia (9.78%), Pseudomonas aeruginosa(6.17%), Enterococcus faecalis(5.32%) and Candida albicans(5.32%) came top. The distribution of pathogens focused on department of geriatrics (22.98%),urology (18.52%), endocrinology (11.32%), nephrology (10.63%) and Intensive Care Unit(9.6%). Extended spectrum β Lactamases(ESBL)-producing bacteria were found in56.78%of Escherichia coli and56.14%of Klebsiella pneumonia, respectively.33.33%Of Methicillin-resistant Staphylococcus aureus (MRSA) and47.06%of Methicillin-resistant coagulase-negative staphylococci (MRCNS) were detected. No isolates of Staphylococci were resistant to linezolid and teicoplanin, while one strain of Staphylococci was found resistant to vancomycin. Enterococcus was100%sensitive to vancomycin.Conclusion Urinary tract infection (UTI) occurs at a high rate in our hospital. Gram-negative bacteria are predominant, of which Escherichia coli accounts for the most common pathogen. Escherichia coli and Klebsiella pneumonia are relatively sensitive to β-lactamase compound (except ampicillin/sulbactam) and Amikacin, which can be used for empirical therapy. Vancomycin, linezolid, teicoplanin, tigecycline are effective for UTI caused by Gram-positive coccus.