| Objective:To investigate the usage of certain traditional Chinese patent medicines prescribed in neurology department of one hospital and analyze the rationality of drugs usage. Methods:Data was collected from all patients discharged from the neurology department of hospital data of neurology dein September2013, the usage of certain traditional Chinese patent medicine was evaluated by calculating utilization rate, pharmacoeconomic analysis, rationality analysis and clinical monitoring. Results:The utilization rate of Chinese medicine was92.6%in the neurology department of this hospital,34traditional Chinese patent medicines were involved, and the most widely used Chinese medicine injection were prescribed for cycle improvement. According to DDDs(defined daily dose system, DDDs) ranking, the top7Chinese patent medicine prescribed were Xingnaojing injection, Danhong injection, Shuxuening injection, Shuxuetong injection, Salvianolate lyophilized powder, Naoxintong capsules and Xueshuantong lyophilized powder. The total monthly money number/DDDs number of Shuxuetong injection, Shuxuening injection and Xueshuantong lyophilized powder were about1, indicating that the usage was reasonable and the medicine cost consistent well with the usage frequency. While the total monthly money number/DDDs number of Xueshuantong lyophilized powder was only0.3, indicating this kind of drug was overprescribed. The DUI(drug utilization index, DUI) of Xingnaojing injection, Danhong injection, Shuxuening injection and Xueshuantong lyophilized powder were all greater than1.0, indicating that the daily dose was reasonable. Data analysis on the top7Chinese patent medicine showed that the usage of Shuxuetong injection and Xueshuantong lyophilized powder was reasonable, the usage of Salvianolate lyophilized powder was totally unreasonable, while the usage of Xingnaojing injection, Danhong injection, Shuxuening injection and Naoxintong capsules were partially reasonable with the unreasonable rates30%,24%,22%and8%, respectively. The unreasonable usage mainly present as over-indication prescription. Conclusions:There was a high utilization of traditional Chinese patent medicine in the neurology department of this hospital, and many varieties were involved. The usage of traditional Chinese patent medicine still have many problems, especially the over-indication prescription.Objective:To investigate the effect of Yuquan Pill on the renal excretion of metformin hydrochloride(MH). Methods:Wistar male rats were divided into two groups randomly, rats in one group were administrated saline (2mL), while rats in the other group were administrated Yuquan pill (2.4g·kg-1) for7days, and then MH (25mg·kg-1) was administrated by tail injection. Urine from different time periods was collected and the concentrations of MH in urine were determined by HPLC method, and the expression of transporter rOct2in kidney was detected by Western blotting analysis. Results:The cumulative excretion (24hours) of MH in Yuquan pill pretreated group (2628.6±557.0μg) was significantly reduced when compared with that in control group (3067.2±538.3μg). The protein expression of renal rOct2in Yuquan pill pretreated group was significantly decreased when compared with that in control group. Conclusions:Yuquan Pill pretreatment could decrease the renal excretion of metformin in rats, the underlying mechanism may be associated with its inhibitory effect on renal rOct2expression. |
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