Correlation Of Intussusception With Rotavirus And Adenovirus Infection In Children

Intussusception is one of the most common pediatric surgical acuteabdominal diseases. Its etiology and pathogenesis are not yet completelyclear. At present, many studies have reported the occurrence ofintussusception in children associated with rotavirus or adenovirusinfection, but there are still disputes.ObjectiveThe purpose of the research is to study the correlation ofintussusception in children with rotavirus and adenovirus infection，toprovide theoretical basis for preventing and reducing the incidence ofintussusception.Materials and methodsIn the experimental group there were59cases from the hospitalizedchildren with intussusception in Changchun Children’s Hospital duringthe period of June2013to January2014, including44boys and15girlsin the age group of3months to3.5years old. In the control group therewere50cases with non-enteric disease of comparable age and gender inthe same period，including38boys and12girls in the age group of4months to3years old. Stool specimens were collected from two groups ofchildren. The samples were detected for rotavirus by the method offluorescence quantitative RT-PCR and colloidal gold devicesimultaneously. The samples were detected for respiratory adenovirus bythe method of fluorescence quantitative PCR, and the enteric adenovirus was detected by colloidal gold device. The data was analyzed by using thesoftware SPSS17.0.ResultsThe stool specimens of the experimental group and the control groupwere tested for rotavirus by the method of fluorescence quantitativeRT-PCR and colloidal gold device. The results were negative. There wasno significant difference between the two groups according to theanalysis of FISHER exact probability method. The fecal specimens forrespiratory adenovirus were detected by using fluorescence quantitativePCR. The proportion of the respiratory adenovirus was37.29%(22/59) inthe experimental group. The proportion of the respiratory adenovirus was6%（3/50）in the control group. The difference was statistically significant(p <0.01) according to statistical analysis. The stool specimens weredetected for enteric adenovirus by using colloidal gold. None of theexperimental group and the control group was positive. There was nosignificant difference between the two groups according to FISHER exactprobability method.Conclusions1. There was no clear correlation of intussusception in children withrotavirus infection.2. This study suggests a causal association between respiratoryadenovirus infection and intussusception in children. There is no evidenceto demonstrate that enteric adenovirus plays a causal role inintussusception.