The Clinical Effective Observation Of The Methood For Clearning Heat-toxin During Dehumidification And Dredging Channel Blockage In The Treament Of Promary Acute Gouty Arthritis

Objective: Depending on randomized controlled group and prospective experimental research methods,this study had a observation at the clinical effection of method for clearing heat-toxin during dehumidification and dredging channel in treatment of primary acute gouty arthritis. The study aim at having a result of the observation and evaluation of its recent clinical efficacy, safety, and the improvement of the quality of daily life in patients with AGA.Thereby we can have a clear cognize that tells us the clinical features and advantages of the method for primary AGA.As a result,the basement of evidence-based medicine to provide effective and reliable basis for this clinical treatments will be offered.Methods:Using experimental approach which took positive drug as randomized control group,74cases of primary acute gouty arthritis in patients met the inclusion criteria was selected. By using a random number remainder grouping method,the74cases of patients were randomly divided into the treatment group (A group of37), the control group of37patients (group B).The treatment group took the medicine (herbs from the proposed prescription dosage form) and NSAIDs (non-steroidal anti-inflammatory drugs (aceclofenac enteric-coated capsules),while the control group took only NSAIDs(aceclofenac enteric-coated capsules).After seven days of treatment cycles,results(such as joint pain, rest,joint tenderness, joint swelling, TCM changes in climate, etc.) before and after medication and observation of clinical signs and symptoms of the two groups of patients and laboratory parameters (such as blood uric acid SUA, dynamic erythrocyte sedimentation rate ESR, serum C-reactive protein CRP, liver function, kidney function) were recorded,. Resting pain VAS(Visual Analogue Scale) score and TCM syndrome score and joint swelling index is calculated before and after treatment.According to " TCM Syndrome Diagnostic efficacy of the standard " in the comparative statistical analysis,the study tried to objectively reflect the traditional Chinese medicine treatment of clearing heat-toxin during dehumidification and dredging channel for primary clinical outcomes of acute gouty arthritis and mske sure the security.Results:1.Before and after the treatment,outcomes of two groups of patients themselves compared proves that both group can significantly reduce joint swelling index, resting pain VAS score, the difference was statistically significant (P<0.05); conducted on two groups of cases, the difference was not statistically significant (P>0.05).2. In the aspect of TCM syndrome score, outcomes of two groups of patients themselves were compared after treatment, the difference was statistically significant (P<0.05), the difference of the controlled group was not statistically significant (P>0.05); conducted on two groups of cases, the difference was statistically significant (P<0.05), and clinical efficacy in the treatment group was better than the controlled group.3. Before and after the treatment,two groups themselves were compared.with uric acid (SUA) improved with a statistically significant difference (P<0.05).The SUA of the controlled group was not statistically significant (P>0.05),the differences of both groups’CRP were statistically significant (P<0.05);conducted on the SUA of two groups of cases,the differences were statistically significant (P<0.05), and the clinical efficacy in the treatment group were better than the comparison groups. The differences between the CRP of the two groups were not statistically significant (P>0.05)Conclusion: TCM treatment of clearing heat-toxin during dehumidification and dredging channel with herbs from the proposed prescription dosage form combined with aceclofenac enteric-coated capsules in the treatment of primary acute gouty arthritis, can reduce serum uric acid (SUA) levels, improve joint pain, joint swelling and medicine syndrome score.And the clinical efficacy was superior to using aceclofenac enteric-coated capsules alone.TCM herbal granules combined with non-steroidal anti-inflammatory drugs shew no significant adverse reactions and side effects but high security.This treatment is effective on the treatment of patients suffering from acute gout gouty arthritis with TCM syndromes of heat accumulation. And this method should be spreaded in clinical practice.