Quantitative Evaluation Of Minimal Invasive Treatment Of Non-compressive Radiculitis With Diffusion Weighted Imaging In Piglets Model

Objective:To explore the value of diffusion-weighted imaging for quantitative monitoring of various minimal invasive treatment of non-compressive radiculitis in piglets model.Methods:12pigs with CT guided induced non-compressive radiculitis were divided into four groups with3swine in each group based on implemented treatment methods. Group A was treated with O2-O3,B with mixed anti-inflammatory liquid,C with collagenase enzyme and D control group.Bilateral epidural nerve root injection, at segments L2-3,L3-4,and L4-5,of specific therapeutic materials were injected to the respective group s.Thereafter,each group underwent preoperative as well as postoperative(at3days,7days,15days) routine coronal T2WI and DWI MRI scan, and immunohistochemical study were performed on nerve root specimens.Analysis of each group in the preoperative and postoperative(3days,7days,15days) ADC value and nerve root CD8positive T lymphocyte count score changes; The correlation between ADC value of nerve root and CD8positive T lymphocyte count score were also analyzed.Results:ADC value of nerve root as well as CD8positive T lymphocyte count of each gruop post3,7and15days of therapy showed declining trend(P <0.05for both).ADC value of nerve root and lymphocyte count score correlated positively,the correlation coefficients were0.806,0.916,0.889,0.644, for group A,B, C and D respectively (P<0.05). Conclusion:Different treatment method can improve the nerve root inflammation,and diffusion-weighted imaging could be used as a non-invasive quantitative monitoring tool for non-compressive radiculitis after minimal invasive treatment.