The Research Of Magnetic Resonance Spectroscopy And Diffusion Weighted Imaging Features In Cervical Cancer

Objcet To investigate the value of*H magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI))at3.0T magnetic resonance(MR) in diagnosing cervical cancer and cervical intraepithelial neoplasia (CIN).Methods1.32patients with cervical lesions (including moderately differentiated carcinoma14cases, poorly differentiated carcinoma9cases, nine cervical intraepithelial neoplasia (CIN))9cases and31healthy volunteers with single-voxelH-MRS and DWI sans at3.0T MRI in:All32patients with cervical lesions were confirmed by histopathology, To quantitative analysis the values of chemical compound peaks(including choline (cho3.2ppm), triglycerides-CH2(lip1.3ppm)) and ADC.2. The cho、 lip and ADC Values were measured and analyzed between the group of cervical lesions and the control group; the control group, the CIN group, and the cervical carcinoma group; The choline、 triglycerides-CH2and ADC Values in different differentiation types of cervical cancer(cervical CIN, moderately differentiated carcinoma and poorly differentiated carcinoma) were also compared among. Finally, to find the reasonable optimal cut-off values of cho、 lip and ADC between cervical lesions and the control group with receive operating characteristic curve(ROC curve)analysis.Result1. The mean cho peak values(mean area under peak) of the31cases of normal control group and the32cases of cervical lesions group were0.61±0.42,3.24±1.87, the cervical lesions group was significantly higher, and have significant difference (P<0.05); The mean lip peak values of the normal control group and the cervical lesions were were0.67±0.46,3.48±1.94, the cervical lesions group was significantly higher, and have significant difference (P<0.05).2. cho peak values of the31cases of normal control group, the9cases of CIN group, the23cases of invasive cervical cancer group were0.61±0.42,0.85±0.56,4.98±2.42; The mean lip peak values were0.67±0.46,1.17±0.78,4.52±2.61, the CIN group was slightly higher than the normal control group, but have no significant difference (P>0.05), cervical carcinoma was significantly higher than the normal control group and the CIN group, and the difference was statistically significant (P<0.05);3. The mean cho peak values of the9cases of CIN group, the14cases of moderately differentiated carcinoma group and the9cases of poorly differentiated carcinoma group were0.85±0.56,4.93±2.75,5.01±2.89; The CIN group was significantly lower than the moderately differentiated carcinoma and the poorly differentiated carcinoma group, and the difference was statistically significant (P<0.05), the poorly differentiated carcinoma group was slightly higher than the moderately differentiated carcinoma group, but the difference was not statistically significant (P>0.05); The mean lip peak values of the CIN group, the moderately differentiated carcinoma group and the poorly differentiated carcinoma group were1.17±0.78,1.98±0.62,5.79±2.05; The poorly differentiated carcinoma group were significantly higher than the CIN group and the moderately differentiated carcinoma, and the difference was statistically significant (P<0.05); the moderately differentiated carcinoma was slightly higher than the CIN group, but the difference was not statistically significant (P>0.05).4.The mean ADC values of the31cases of normal control group, the32cases of cervical lesions group, the23cases of invasive cervical cancer group, the9cases of CIN group, the14cases of moderately differentiated carcinoma group, the9cases of poorly differentiated carcinoma group, were(1.49±0.25)x1O-3mm-2/s (0.95±0.22)x10-3mm2/s、(0.83±0.18)x10-3mm2/s、(1.06±0.14)x10-3mm2/s (0.88±0.16)x10-3mm2/s、(0.79±0.12)x10-3mm2/s, the cervical lesions group was significantly lower than the normal control group, and have significant difference (P <0.05); The mean ADC values of the normal control group, the CIN group and the invasive cervical cancer group was reduced in order, and the differences were statistically significant (P<0.05); The mean ADC values of the CIN group, the moderately differentiated carcinoma group and the poorly differentiated carcinoma was reduced in order, but only the difference between the CIN group and the poorly differentiated carcinoma had statistical significance (P<0.05).Conclusion (1)The cho and lip peak values in the cervical lesions group were significantly increased, were significantly higher than the control group;(2)The cho and lip peak values in the CIN group, the invasive cervical cancer group were all increased, but the CIN group increased was not statistically significant;(3)The cho peak values in different differentiation types of cervical cancer increased different, the poorly differentiated carcinoma was increased most significant,the moderately differentiated carcinoma was secondly (slightly lower than the poorly differentiated carcinoma), the CIN only had a slightly increased;(4)The lip peak values in different differentiation types of cervical cancer increased different, the poorly differentiated carcinoma was increased most significant,the CIN only had a slightly increased; the moderately differentiated carcinoma was slightly higher than the CIN;(5)The mean ADC values of the cervical lesions group, the invasive cervical cancer were significantly lower than the normal control group; The mean ADC values of the CIN group, the moderately differentiated carcinoma group and the poorly differentiated carcinoma group were reduced in order.