Clinical Application Of Dexmedetomidine Plus Ropivacaine For Postoperative Patient-controlled Analgesia After Continuous Brachial Plexus Block

Objective: This study aimed at evaluating the clinical effects ofdexmedetomidine plus ropivacaine for postoperative patient-controlledanalgesia after continuous brachial plexus block.Method: Eighty patients undergoing unilateral upper extremitysurgery in the first hospital of jilin university from February2013toDecember2013. The patients were randomly divided into two groupswith forty cases each,the dexmedetomidine plus ropivacaine group (Dgroup) and the ropivacaine group (R group).After arrival in operatingroom, every patient was carried out monitoring of electrocardiogram(ECG), heart rate (HR), noninvasive blood pressure (NIBP), bloodoxygen saturation (SpO2). The continuous interscalene brachial plexusblock was performed under the guidance of nerve stimulator.The firstdose injection was2%lidocaine10ml plus0.75%ropivacaine10ml.Then connect analgesia,the formulation of group D was given withdexmedetomidine100μg plus0.225%ropivacaine100ml and those ingroup R with0.225%ropivacaine100ml alone in a basal dose of2ml/h,patient-controlled analgesia dose of0.5ml and lookout time of15min.General information,postoperative analgesia and side effects were recorded.Statistical processing was completed with SPSS18.0,P<0.05isconsidered as statistical significance.Result:1. General information in the two groups had no statisticalsignificance.2.The visual analogue scale (VAS) of patient in group D wassignificantly lower than group R at12h and24h after surgery (P<0.05),there Was no statistical difference in scores at0h,3h and6h after surgery.3. Compared with group R,the total number of presses in group D wassignificantly reduced24hours after surgery(P<0.05).4. There were3patients in group D that required other analgesia agent and in group Rwere5patients,the difference was not statistically significant.5. Thesatisfaction of two group of patients have no statistics significance.6.There was on adverse event occurred in patients of two groups.Conclusion: Addition of dexmedetomidine to ropivacaine has betteranalgesia effect than ropvicaine alone for postoperative patient-controlledanalgesia after continuous interscalene brachial plexus block, and have noadverse event occurred．...