A Study Of Neural Stem Cell Therapy For Infantile Cerebral Palsy

Cerebral palsy (CP) is a disorder that resulting from a permanent,non-progressive defect or lesion of the fetal or infant brain aged from pregnancy tofirst months after birth. It is a central motor dysfunction affecting posture andmovement, often accompanied by disturbances of intelligence, sensation,communication and behavior, and by other problems. CP can happen at any timeduring the first2years of life.A lot of progress in perinatal medicine has been achieved over the past dozenyears, and the availability of neonatal intensive care has improved outcomes forinfants with CP, but the morbidity of CP is still very high all over the world. It is alarge financial and emotional burden on individuals, families and societies. CP is asymptom complex rather than a specific disease. CP can be caused by manyabnormalities or disruption in brain development, but the exact trigger of thoseabnormalities isn’t known. There is no specific treatment for this disease. At present,the treatment programs for CP encompass rehabilitation therapy, pharmacologictreatments and TCM treatment, and so on. While many of these treatments are helpful,none facilitate in reparative recovery of damaged brain. Stem cell technology giveshope of effective treatment for a variety of malignant and non-malignant diseases,including infantile cerebral palsy, through stem cell transplantation and gene therapy.Neural stem cell (NSC) transplantation has been reported to be effective in animalmodels as well as in patients with other degenerative neurological disorders, whichraises new possibilities for the treatment of CP. This paper will systematically reviewthe epidemiology, comprehensive therapy and stem cell treatment options, andprovide basis for the popularization and application of NSCs transplantation in thetreatment of CP.