Curcumin In Heart Failure Rat Mode Function Research

objective to establish heart failure rats model, based on this model are respectively studied curcumin in heart failure rat blood flow dynamics and myocardial tissue pathology change effect, at the same time analysis Brain natriuretic peptide in curcumin treatment of heart failure mechanism.Methods set JiaShouShu group, the control group, low dose group (50mg/kg curcumin), medium dose group (75mg/kg) and high dose group (100mg/kg), in order to rats signs change, rat body weight, heart heavy, heart heavy/weight, heart rate and gas change and rats blood dynamics change to evaluate heart failure rats model is stable and reliable; In the treatment of12weeks after the left ventricular systolic blood pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular pressure change is the biggest rate (+dp/dtmax and-dp/dtmax) and myocardial tissue HE dyeing as evaluation curcumin in heart failure rat influence index; Acquisition rat myocardial thick cell tissue, using Western blot test Caveolin-3expression and ELISA detection BNP expression to reveal different dosages curcumin treatment of heart failure process Caveolin-3and BNP expression rule.Results heart failure model rats compared with controls, there is obvious difficulty breathing aggravate, death, hair colour and lustre is abnormal and abnormal activities; And weight loss, heart heavy and heart heavy/weight ratio decreased, fast heart rate and oxygen saturation decline; Left ventricular systolic blood pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular pressure change is the biggest rate (+dp/dtmax and-dp/dtmax), aortic systolic blood pressure (ASP), aortic diastolic pressure (ADP) and between the aorta and left ventricular pressure difference (TAG), can be used as direct response heart failure model is built; Curcumin treated rats left ventricular systolic blood pressure (LVSP), left ventricular diastolic pressure (LVEDP) and left ventricular maximum contraction/diastolic velocity (plus or minus dp/dtmax) were JiaShouShu group recovered to the same level of myocardial tissue pathological dyeing are returned to normal, did not see the myocardial cell swelling, gap decreases and the myocardial fibers limitations fracture, myocardial mass in the phenomenon such as blood vessels; As the dosage of the curcumin increases, Caveolin-3expression gradually increase, with the dosage of curcumin increases, BNP expression gradually reduced.Discuss curcumin has cure or alleviate heart failure rat illness effect, and with the increase of the dose of curcumin in the treatment of curcumin, the better the results; Curcumin may through some mechanism or by changing the Caveolin-3and BNP expression and play heart failure treatment effect.