Exploration Of The Diagnostic Value And The Disease Assessment Of The Copeptin In The Community Acquired Pneumonia

Objective: To investigate copeptin（CPP）for the diagnostic value and conditionassessment on community acquired pneumonia (CAP).Methods: Experiment group include55cases of the CAP patients, and controlgroup include20cases of the connective tissue disease complicated with interstitiallung disease (CTD-ILD) and15cases of healthy adults. According to the PSI score, thesubjects of the CAP group were divided into the low-risk group (0-90points) n=30, themedium risk group (91-130points) n=11, and the high-risk group (>130)n=14. On thebasis of CURB-65score, the patients were divided into the low-risk group(0-1points ornone toxemia)n=41,the medium risk group(2points, combined toxemia)n=6, and thehigh-risk group(3-5points,with severe sepsis or septic shock)n=8.According to thediagnosis criteria of the ATS for severe pneumonia, the subjects of the CAP group weredivided into severe(n=15) and non-severe(n=40) pneumonia group. The level of serumCPP was measured by the method of ELISA, and automatic biochemical analyzerdetermination of serum CRP(C-reactive protein, CRP)level, and double-antibodysandwich immunoassay luminescence determination of serum PCT (procalcitonin,PCT)levels. All data was analyzed by SPSS17.0statistical analysis software,and P<0.05was considered statistically significant.Results:1.The serum levels of CPP, CRP, PCT in the CAP group and sputum culture positivegroup were significantly higher than that in the healthy group, and the difference wasstatistically significant (P <0.05). Compared with CTD-ILD group, the serum levels ofCPP and PCT in the CAP group and sputum culture positive group were significantlyhigher and the difference were statistically significant (P<0.05).2．The levels of the biomarkers were compared among the low-risk, medium risk and high-risk groups classified by PSI and CURB-65. The serum level of CPP in thehigh-risk group was significantly higher than that of the low and medium risk groups,the difference was statistically significant (P<0.05).The serum level of PCT in thehigh-risk group was significantly higher than that of medium-risk group (P<0.05), thedifference was statistically significant (P<0.05). The serum level of CRP in themedium-risk group was significantly higher than that of low-risk group (P<0.05), thedifference was statistically significant (P<0.05). In the severe CAP of ATS standard, theserum level of CPP in severe pneumonia group was significantly higher than that of thenon-severe pneumonia group, and statistically significant between two groups(P<0.05),while the levels of CRP and PCT had no statistical significance (P>0.05).3．The correlation of each biomarker levels and PSI or CURB-65score in CAPgroup showed: The CPP level positively related to PSI and CURB-65score, and thecorrelation was statistically significant（P<0.05）.However there was no statisticallysignificant correlation between the CPR or PCT level and PSI or CURB-65score（P>0.05）.Conclusions:1．The serum level of CPP had a certain reference value for the diagnosis of CAP.2．The serum level of CPP increased with the pneumonia severity and could reflectthe severity of CAP patient.