The Clinical Research Of The Characteristics Of Lipid Metabolism And Its Relationship With Prealburmin In Maintenance Hemodialysis Patients

Objective To investigate the characteristics of lipid metabolism and itsrelationship with prealbumin，and find out these two factors,significations inevaluate nutritional status in maintenance hemodialysis(MHD) patients。Methods The90MHD patients were researched.Detection indicators: serumtriglyceride(TG)，totle cholesteml(TC)，high density hpoprotein(HDL-c)，lowdensity lipoprotein(LDL-c)， apolipoprotein AI (Apo-AI)、 very low densitylipoprotein (VLDL-c),， apolipoprotein B(Apo-B)， and albumin(Alb),prealbunin (PA), C-reactive protein(CRP).(1)Baised on the level of PA,the90patients were divided to2groups:group A(PA≥300mg/L)and B.（PA<300mg/L）Compared the differences of lipid metabolism between twogroups.(2) Analysised the correlation of PA and various indicators of lipid metabolism.(3)Compared the morbidity of cardiovascular and cerebrovasculardiseases in group A and B. Result (1) Compared to the control group, thelevels of TC、HDL-c were decreased significantl(p<0.05) in the group A andB,while the levels of TG、TC、LDL-c、VLDL-c、Apo-AI and Apo-B in the groupB were decreased significantl than the group A.(p<0.05).(2) The levels of PAwas positively correlated to the levels of TG(ｒ=0.253，P=0.016)、TC（ｒ=0.392，P=0.000）、HDL-C（ｒ=0.226，P=0.033）、LDL-C（ｒ=0.343，P=0.001）、VLDL-C（ｒ=0.377，P=0.000）、ApoAI（ｒ=0.368，P=0.000）、ApoB（ｒ=0.344，P=0.001）(p<0.05),while negatively correlated to the levels of the levelCRP （ｒ=-0.297， P<0.01）.（3） The morbidity of cardiovascular andcerebrovascular diseases in group B was higher than the group A（X2=6.156,P=0.023）.Conclusion There were lipid metabolism in MHD, thelevels of PA was positively correlated to the levels of lipid;it would be moredanger to occur the cardiovascular and cerebrovascular diseases. The low levelsof TC and PA were the poor prognosis indicators.