Clinical Study On The Relation Of The Clinical Relevant Factors Of Postoperative Gastric Cancer Patients Live For5Years With Its TCM Syndrome Classification

Objective:Discussing the relationship between the postoperative gastric cancer patients lived for5years with TCM syndromes classification and clinical relevant factors. Comparing type differences between justification of relapse and recurrence in patients, in order to improve the objective and the accuracy of traditional Chinese medicine, the use of traditional Chinese medicine to predict the recurrence of tumor, and early prevention of recurrence of gastric cancer with TCM.Method:A total of150gastric cancer patients who received radical resection from Jan.2005to Dec.2007were enrolled. The data concerning TCM syndromes classification and clinical relevant factors were analyzed retrospectively.Results:(1)150patients with gastric cancer, Liver-stomach disharmony syndrome, Deficiency-cold in spleen and stomach syndrome, Stomach heat injury Yin syndrome, Deficiency of Qi and blood syndrome, phlegm wet condensation syndrome, and Qi stagnation and blood stasis syndrome accounted for22.0%,21.3%,16.7%,16.7%,12.7%and10.7%.(2)Recurrence or transfer status of patients with different TCM syndrome types had significant difference (p<0.05), and Qi stagnation and blood stasis syndrome recurrence or transfer rate is highest. Compared with the other5groups syndrome, it had significant difference (p<0.05).(3) Six kinds of syndromes in the primary focal tumor diameter distribution failed to find prognostic factors in the statistical difference (p>0.05);(4)In tumor infiltrating degree, T1, T2of Liver-stomach disharmony syndrome, Stomach heat injury Yin syndrome, and phlegm wet condensation had a high proportion; T3, T4of Deficiency-cold in spleen and stomach syndrome, Deficiency of Qi and blood syndrome, and Qi stagnation and blood stasis syndrome had a high proportion. Compared with Liver-stomach disharmony syndrome, Stomach heat injury Yin syndrome, and phlegm wet condensation syndrome, Qi stagnation and blood stasis syndrome, Deficiency-cold in spleen and stomach syndrome and Deficiency of Qi and blood syndrome had significant difference (p<0.05) respectively.(5)The total of NO and N1in regional lymph node metastasis status was68%, which made chiefly by Liver-stomach disharmony syndrome, Deficiency-cold in spleen and stomach syndrome, Stomach heat injury Yin syndrome, and Deficiency of Qi and blood syndrome Compared with Liver-stomach disharmony syndrome, Stomach heat injury Yin syndrome, Deficiency-cold in spleen and stomach syndrome and Deficiency of Qi and blood syndrome, phlegm wet condensation syndrome and Qi stagnation and blood stasis syndrome had significant difference (p<0.05) respectively.(6) In the pathological types of TCM syndrome types, Qi stagnation and blood stasis syndrome had significant difference (p<0.05) compared with Deficiency-cold in spleen and stomach syndrome, and Deficiency of Qi and blood syndrome.(7) Six kinds of syndromes in histologic classification distribution failed to find prognostic factors in the statistical difference (p>0.05);(8)In clinical stage I, Deficiency-cold in spleen and stomach syndrome was the most common (31%), Qi stagnation and blood stasis syndrome was the most rare (8.6%);In clinical stage II, the proportions of Liver-stomach disharmony syndrome(27.7%), and Deficiency of Qi and blood syndrome(23%)were higher than others; In clinical stage III, the proportions of Qi stagnation and blood stasis syndrome was the highest (25%),phlegm wet condensation syndrome was the lowest (4.2%);Compared with Liver-stomach disharmony syndrome, Qi and blood syndrome, Deficiency-cold in spleen and stomach syndrome had significant difference (p<0.05). Conclusion: Liver-stomach disharmony syndrome, and Deficiency-cold in spleen and stomach syndrome, are common in the TCM syndrome classifications of gastric cancer patients,who received radical resection and lived for5years.Recurrence or metastasis is closely related with Qi stagnation and blood stasis syndrome. Original site of tumor diameter and histological grading have no obvious correlation with TCM syndrome classification. Tumor infiltrating degree, regional lymph node metastasis status, pathological type, and clinical stage are four indexes for microcosmic syndrome differentiation of TCM in gastric cancer.