Progress Of Renin Inhibitor And Pro-renin/renin Receptor Blocker

The paper introduces the progress of renin inhibitor and pro-renin/renin receptor blocker Aliskiren. Aliskiren exhibits a long half-lifepharmacology and by bile excretion pharmacokinetics. Aliskiren is a safeand effective antihypertensive agent that can be used as monotherapy or incombination with other agents to provide additional option to improve BPcontrol. Review the new approaches to protect target organ, aliskiren iseffective in attenuating myocardial remodeling, improving heart failure,preventing atherosclerosis progression, improving insulin resistance andprotecting renal function.