Exprexsxion Of CIP2A In Laryngeal Squamous Cellcarcinoma And Its Clinical Significance

Objective：Collect the data of patients with laryngeal squamous cellcarcinoma and cancer tissues to detect the CIP2A expression in laryngealcarcinoma and the correlation between CIP2A and the basic and clinicalpathological parameters. Follow up the detected patients for survival andrecurrence and to analyze the effect of CIP2A expression on prognosis of thepatients. Methods: We collected61laryngeal cancer tissues (containing40adjacent normal tissues),8cpapillary tumor and9atypical hyperplasia. TheCIP2A level was detected by immunohistochemistry staining. TheMann-Whitney or Kruskal-Wallis tests were used to analyze the differencesbetween all the tissues mentioned above, and the relation between CIP2Aand clinical characteristics. Kaplan-Meier survival analysis and COXregression analysis were used for effect of CIP2A expression on prognosis oflaryngeal cancer. Results: The expression of CIP2A was high in laryngealsquamous cell carcinoma, and low in atypical hyperplasia and laryngealpapilloma (P<0.05). CIP2A immunoreactivity, tested in61laryngeal cancers,was negative in11(18%), weakly positive in13(21.3%), moderately positive in25(40.9%), and strong positive in12(19.6%) cases. The highexpression of CIP2A was not related with age, sex, smoking and alcoholassumption. Whereas, the high CIP2A level in laryngeal cancer werecorrelated with tumor grade, clinical stage, lymphatic metastasis, andhistological differentiation (P<0.05).Higher CIP2A expressiondemonstrated poorer survival, and was associated with shorteroverall-survival and disease-free survival. Conclusion: The laryngealcancer presented higher CIP2A than the adjacent normal tissues and benigntissues; CIP2A overexpression was correlated with certain clinicalcharacteristcs (TNM and differentiation); as an independent prognosticfactor for laryngeal carcinoma, CIP2A may be useful in predicting theoutcome of laryngeal cancer.