The Effect Of Selenium Supplementation On Serum Thyroid Antibodies Levels In Patients With Autoimmune Thyroiditis

Objective: To observe the impact of selenium supplementation therapyon thyroid antibodies in patients with autoimmune thyroiditis. Method:Patients with autoimmune thyroiditis were divided into selenium group (38cases) and control group (38cases). The levels of FT3、FT4、TSH、TgAband TPOAb in the baseline were measured, and we also tested theirconcentration after3th，6th，12th month treatment respectively. Results:The levels of FT3, FT4and TSH does not have a statistically significantdifference between the control group and the selenium group, while thelevels of TgAb and TPOAb all decreased after seleniumsupplementation.The most obvious was TPOAb,which decreasedsignificantly after3month treatment.The baseline was614.6IU/mL（121.0IU/mL,969.0IU/mL）, the levels droped to346.4IU/mL (86.9IU/mL,737.45IU/mL) after3month treatment.The control groupincreased from399.30IU/mL (101.66IU/mL,678.38IU/mL) to443.95(211.4IU/mL,1014.75IU/mL), P=0.034(P <0.05), changes ofTPOAb is statistically significance. Conclusion: Selenium supplementation therapy may reduce the antibody levels of autoimmune thyroiditis patients,especially the change of TPOAb levels.