Study On The Relation Of Plasma Homocysteine With Mild Cognitive Impairment In Parkinson’s Disease

Objective The purpose is to explore plasma Hcy levels in PD-MCI patients; To explore the relationship between varying degrees of cognitive dysfunction in PD-MCI patients and the level of Hcy; To explore the related influence factors of cognitive function in PD patients without dementia.Methods I collected104cases PD patients、52cases with other nervous system diseases and52cases of healthy controls in the Changde first people’s hospital from July2011to October2012. I have completed the following task:1.Collect all the detailed data of the three groups2. Test the H-Y stages of PD patients and cognitive level score in patients with PD3. Detect plasma Hcy levels in all study object4. According to the levels of Hcy in the three groups,comparison the differences of Hcy level in PD-MCI,PD-CNT and normal controls; Analysis of the relationship between cognitive domains ratings in PD-MCI patients and Hcy levels; Analysis cognitive function related factors of non-demented PD patients.Result1. There were significant differences about Hcy level in the PD group (14.64±3.12),nervous system disease control group (11.62± 2.19) and healthy control group (12.66±2.32), the level of Hcy in disease control group and the healthy control group was no significant difference.2. In non--demented PD patients, the cognitive scores were positive correlated with the education (R2=0.604, P<0.01), and were negative correlated with the Hcy level (R2=0.713, P<0.01),age (R2=0.694, P<0.01) and H-Y stages (R2=0.376, P<0.01),but there were not correlated with disease duration.3.IN104PD patients, PD CNT71cases (68.27%), PD-MCI25cases (24.04%). The average level of Hcy between PD-MCI group (17.84±1.77) and PD-CNT group (13.12±2.27) was significant difference (P<0.01).4. In PD-MCI patients,the serum Hcy level was positive correlation with memory (R2=0.392, P<0.01) and Visuospatial,executive function (R2=0.336, P<0.01)Conclusions1.High plasma Hcy levels may result in PD-MCI, especially result in memory and visuospatial executive function.2. The level of education,Hcy level,age,H-Y stage have an impact on cognitive function in non-demented PD patients.