| Objective:Explore the behavioural characteristics of anticipatory anhedonia and consummatory anhedonia in patients with schizophrenia, and to disscuss the mechanism of anhedonia from the perspective of motivation system. And the influence of cognitive function in evaluating the machining process for hedonic.Methods:The subjects of case group were Selected from the outpatients of the second Xiangya Hospital and matched with the health individual as control group.1)using the home-made questionnaire to gather the basic information of the subjects.2) The patient’s clinical diagnostic assessment to determine by a chief physician3) Diagnostic criteria for the DSM-4schizophrenia diagnostic criteria.4) The PANSS scale for the assessment of the patient’s symptoms.5) The Snaith-Hamilton Pleasure Scale was used to evaluate the degree of anhedonia Half months in patients with schizophrennia6) Using the Temporal Experience of Pleasure Scale to measure the anticipatory happiness and consummatory happiness of all the subjects.7) Using the Digital Span Backward(DSPB) and Rey auditory verbal learning (RAVL)test to evaluate the memory of all the subjects.8) Using Motivated tasks which was made by Heerey and Gold to assess the anticipatory and consummatory components of motivation system.Results:At last we51schizophrenia and50healthy persons were selected as the subjects. The case group and control group all produced appropriate response to different stimulus.In Motivated tasks the case group total button presses per second (7.15±10.66) has significant differences with contol group (26.99±12.02), and average button presses per second in different stimulus has significant differences (p=0.00) between the case group and control group too.There weren’t have any difference between the two group of the score of consummatory subscale in TEPS,But in Anticipatory subscale the control group scored (43.58±4.54) significantly higher than case group (38.39±5.31). The score of the TEPS were related to the pleasantness ratings of positive picture (r=-.329, p=.001), and the pleasantness ratings of negtive picture (r=.333, p=.001), were not related to the pleasantness ratings of the neutal pictures and the total pictures. The score of Anticipatory subscale in TEPS were related to the anticipatory button presses per second, but the score of consummatory subscale were not related to the consummatory button presses per second.The scores of DSPB and AVLT have significiant differences(p=0.000). The score of DSPB were related to the pleasantness ratings (r=.440, p=.000),not arousal ratings. The score of AVLT were related to the pleasantness ratings (r=.296, p=.003) not arousal ratings (r=.118, p=.244). Conclusion:The characteristics of anhedonia in schizophrenia are consummatory pleasantness remain intact, but the patients can not usefully to represent the emotion associated with future activities,as a result, Anticipatory pleasantness were damaged. In other word, the connectivity between motion and behavior caused by internal representation stimulus were damaged.Abnormalities in consolidation of emotional memories was one of the causes for the anticipatory anhedonia. These all because the decline of Long-term memory to the information of emotion. The patients with Schizophrenia can not accurately perceive the positive emotional experiences. |
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